| Literature DB >> 15618702 |
Mayumi Saeki1, Shogo Ozawa, Yoshiro Saito, Hideto Jinno, Tetsuya Hamaguchi, Hiroshi Nokihara, Yasuhiro Shimada, Hideo Kunitoh, Noboru Yamamoto, Yuichiro Ohe, Yasuhide Yamada, Kuniaki Shirao, Manabu Muto, Kiyomi Mera, Koichi Goto, Hironobu Ohmatsu, Kaoru Kubota, Seiji Niho, Ryutaro Kakinuma, Hironobu Minami, Atsushi Ohtsu, Teruhiko Yoshida, Nagahiro Saijo, Jun-ichi Sawada.
Abstract
Three novel single nucleotide polymorphisms (SNPs) were found in the UDP-glucuronosyltransferase (UGT) 1A10 gene from 24 Japanese patients with various cancers who were administered the anti-tumor drug, irinotecan (CPT-11). The detected SNPs were as follows: 1) SNP, MPJ6_U1A003; GENE NAME, UGT1A10; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5'-CAGATGCCATGAC/TTTTCAAGGAGAG-3'. 2) SNP, MPJ6_U1A004; GENE NAME, UGT1A10; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5'-CCTAGAAATAGCC/TTCTGAAATTCTC-3'. 3) SNP, MPJ6_U1A030; GENE NAME, UGT1A10; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5'-GGTTGTAGTCATG/ACCAGAGGTGAGT-3' All the three SNPs were located in exon 1 and their frequencies were all 0.021. Among these SNPs, MPJ6_U1A003 and U1A030 resulted in amino acid alterations, T202I and M59I, respectively. The third SNP, MPJ6_U1A004, introduced a synonymous amino acid change (A231A).Entities:
Year: 2002 PMID： 15618702 DOI： 10.2133/dmpk.17.488
Source DB: PubMed Journal: Drug Metab Pharmacokinet ISSN： 1347-4367 Impact factor: 3.614