| Literature DB >> 156184 |
T J Beeler, I Jona, A Martonosi.
Abstract
Ionomycin, a recently discovered calcium ionophore, inhibits the ATP-dependent active Ca2+ transport of rabbit sarcoplasmic reticulum vesicles at concentrations as low as 10(-8) to 10(-6) M. The effect is due to an increase in the Ca2+ permeability of the membrane which is also observed on liposomes. The inhibition of Ca2+ uptake is accompanied by an increase in the Ca2+-sensitive ATPase activity of sarcoplasmic reticulum vesicles.Entities:
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Year: 1979 PMID： 156184
Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157