Literature DB >> 15618337

A signalling role for muscle glycogen in the regulation of pace during prolonged exercise.

H G L Rauch1, A St Clair Gibson, E V Lambert, T D Noakes.   

Abstract

INTRODUCTION: In this study we examined the pacing strategy and the end muscle glycogen contents in eight cyclists, once when they were carbohydrate loaded and once when they were non-loaded.
METHODS: Cyclists completed 2 hours of cycling at approximately 73% of maximum oxygen consumption, which included five sprints at 100% of peak sustained power output every 20 minutes, followed immediately by a 1 hour time trial. Muscle biopsies were performed before and immediately after exercise, while blood samples were taken during the 2 hour steady state rides and immediately after exercise.
RESULTS: Carbohydrate loading improved mean power output during the 1 hour time trial (mean (SEM) 219 (17) v 233 (15) W; p<0.05) and enabled subjects to use significantly more muscle glycogen than during the trial following their normal diet. Significantly, the subjects, kept blind to all feedback except for time, started both time trials at similar workloads ( approximately 30 W), but after 1 minute of cycling, the workload average 14 W higher throughout the loaded compared with the non-loaded time trial. There were no differences in subjects' plasma glucose and lactate concentrations and heart rates in the carbohydrate loaded versus the non-loaded trial. Of the eight subjects, seven improved their time trial performance after carbohydrate loading. Finishing muscle glycogen concentrations in these seven subjects were remarkably similar in both trials (18 (3) v 20 (3) mmol/kg w/w), despite significantly different starting values and time trial performances (36.55 (1.47) v 38.14 (1.27) km/h; p<0.05). The intra-subject coefficient of variation (CV) for end glycogen content in these seven subjects was 10%, compared with an inter-subject CV of 43%.
CONCLUSIONS: As seven subjects completed the time trials with the same end exercise muscle glycogen concentrations, diet induced changes in pacing strategies during the time trials in these subjects may have resulted from integrated feedback from the periphery, perhaps from glycogen content in exercising muscles.

Entities:  

Mesh:

Substances:

Year:  2005        PMID: 15618337      PMCID: PMC1725021          DOI: 10.1136/bjsm.2003.010645

Source DB:  PubMed          Journal:  Br J Sports Med        ISSN: 0306-3674            Impact factor:   13.800


  30 in total

1.  Determinants of the variability in respiratory exchange ratio at rest and during exercise in trained athletes.

Authors:  J H Goedecke; A St Clair Gibson; L Grobler; M Collins; T D Noakes; E V Lambert
Journal:  Am J Physiol Endocrinol Metab       Date:  2000-12       Impact factor: 4.310

2.  Reduced neuromuscular activity and force generation during prolonged cycling.

Authors:  A St Clair Gibson; E J Schabort; T D Noakes
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2001-07       Impact factor: 3.619

Review 3.  How do you feel? Interoception: the sense of the physiological condition of the body.

Authors:  A D Craig
Journal:  Nat Rev Neurosci       Date:  2002-08       Impact factor: 34.870

4.  Specific determination of blood glucose with o-toluidine.

Authors:  A HYVARINEN; E A NIKKILA
Journal:  Clin Chim Acta       Date:  1962-01       Impact factor: 3.786

5.  Concentration of triglycerides, phospholipids and glycogen in skeletal muscle and of free fatty acids and beta-hydroxybutyric acid in blood in man in response to exercise.

Authors:  L A Carlson; L G Ekelund; S O Fröberg
Journal:  Eur J Clin Invest       Date:  1971-01       Impact factor: 4.686

6.  Diet, muscle glycogen and physical performance.

Authors:  J Bergström; L Hermansen; E Hultman; B Saltin
Journal:  Acta Physiol Scand       Date:  1967 Oct-Nov

7.  Muscle glycogen during prolonged severe exercise.

Authors:  L Hermansen; E Hultman; B Saltin
Journal:  Acta Physiol Scand       Date:  1967 Oct-Nov

8.  Cell damage excites nociceptors through release of cytosolic ATP.

Authors:  S P Cook; E W McCleskey
Journal:  Pain       Date:  2002-01       Impact factor: 6.961

9.  Muscle glycogen synthesis after exercise: an enhancing factor localized to the muscle cells in man.

Authors:  J Bergström; E Hultman
Journal:  Nature       Date:  1966-04-16       Impact factor: 49.962

10.  Evidence for neuromuscular fatigue during high-intensity cycling in warm, humid conditions.

Authors:  D Kay; F E Marino; J Cannon; A St Clair Gibson; M I Lambert; T D Noakes
Journal:  Eur J Appl Physiol       Date:  2001 Jan-Feb       Impact factor: 3.078

View more
  42 in total

1.  The effects of carbohydrate intake and muscle glycogen content on self-paced intermittent-sprint exercise despite no knowledge of carbohydrate manipulation.

Authors:  Melissa Skein; Rob Duffield; Bradley T Kelly; Frank E Marino
Journal:  Eur J Appl Physiol       Date:  2011-12-03       Impact factor: 3.078

2.  Limitation of physical performance in a muscle fatiguing handgrip exercise is mediated by thalamo-insular activity.

Authors:  Lea Hilty; Lutz Jäncke; Roger Luechinger; Urs Boutellier; Kai Lutz
Journal:  Hum Brain Mapp       Date:  2010-12-10       Impact factor: 5.038

Review 3.  What are the Physiological Mechanisms for Post-Exercise Cold Water Immersion in the Recovery from Prolonged Endurance and Intermittent Exercise?

Authors:  Mohammed Ihsan; Greig Watson; Chris R Abbiss
Journal:  Sports Med       Date:  2016-08       Impact factor: 11.136

4.  Pacing strategies during repeated maximal voluntary contractions.

Authors:  I Halperin; S J Aboodarda; F A Basset; J M Byrne; D G Behm
Journal:  Eur J Appl Physiol       Date:  2014-03-23       Impact factor: 3.078

Review 5.  The role of information processing between the brain and peripheral physiological systems in pacing and perception of effort.

Authors:  Alan St Clair Gibson; Estelle V Lambert; Laurie H G Rauch; Ross Tucker; Denise A Baden; Carl Foster; Timothy D Noakes
Journal:  Sports Med       Date:  2006       Impact factor: 11.136

6.  Middle cerebral artery blood flow velocity during a 4 km cycling time trial.

Authors:  Ben Rattray; Brittany A Smale; Joseph M Northey; Disa J Smee; Nathan G Versey
Journal:  Eur J Appl Physiol       Date:  2017-04-13       Impact factor: 3.078

7.  Effect of altered pre-exercise carbohydrate availability on selection and perception of effort during prolonged cycling.

Authors:  N A Johnson; S R Stannard; P G Chapman; M W Thompson
Journal:  Eur J Appl Physiol       Date:  2006-06-24       Impact factor: 3.078

Review 8.  Distribution of power output during cycling: impact and mechanisms.

Authors:  Greg Atkinson; Oliver Peacock; Alan St Clair Gibson; Ross Tucker
Journal:  Sports Med       Date:  2007       Impact factor: 11.136

Review 9.  Validity, reliability and sensitivity of measures of sporting performance.

Authors:  Kevin Currell; Asker E Jeukendrup
Journal:  Sports Med       Date:  2008       Impact factor: 11.136

Review 10.  Describing and understanding pacing strategies during athletic competition.

Authors:  Chris R Abbiss; Paul B Laursen
Journal:  Sports Med       Date:  2008       Impact factor: 11.136

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.