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Literature DB >> 15618207

Detection of gliotoxin in experimental and human aspergillosis.

Russell E Lewis¹, Nathan P Wiederhold, Jingduan Chi, Xiang Y Han, Krishna V Komanduri, Dimitrios P Kontoyiannis, Randall A Prince.

Abstract

Gliotoxin was measured in the lungs (mean, 3,976 +/- 1,662 ng/g of tissue) and sera (mean, 36.5 +/- 30.28 ng/ml) of mice with experimentally induced invasive aspergillosis (IA), and levels decreased with antifungal therapy. Gliotoxin could also be detected in the sera of cancer patients with documented (proven or probable) IA.

Entities: Disease Species

Mesh：

Substances：
Gliotoxin
Amphotericin B

Year: 2005 PMID： 15618207 PMCID： PMC538950 DOI： 10.1128/IAI.73.1.635-637.2005

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

17 in total

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Authors: J F Tomee; H F Kauffman
Journal: Clin Exp Allergy Date: 2000-04 Impact factor: 5.018

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Authors: J L Richard; T J Dvorak; P F Ross
Journal: Mycopathologia Date: 1996 Impact factor: 2.574

4. Itraconazole preexposure attenuates the efficacy of subsequent amphotericin B therapy in a murine model of acute invasive pulmonary aspergillosis.

Authors: Russell E Lewis; Randall A Prince; Jingduan Chi; Dimitrios P Kontoyiannis
Journal: Antimicrob Agents Chemother Date: 2002-10 Impact factor: 5.191

5. Amphotericin B enhances the synthesis and release of the immunosuppressive agent gliotoxin from the pulmonary pathogen Aspergillus fumigatus.

Authors: Emer P Reeves; Thomas Murphy; Paul Daly; Kevin Kavanagh
Journal: J Med Microbiol Date: 2004-08 Impact factor: 2.472

6. Identification of an agent in cultures of Aspergillus fumigatus displaying anti-phagocytic and immunomodulating activity in vitro.

Authors: A Müllbacher; P Waring; R D Eichner
Journal: J Gen Microbiol Date: 1985-05

7. Aspergillosis caused by non-fumigatus Aspergillus species: risk factors and in vitro susceptibility compared with Aspergillus fumigatus.

Authors: Harrys A Torres; Gustavo A Rivero; Russell E Lewis; Ray Hachem; Issam I Raad; Dimitrios P Kontoyiannis
Journal: Diagn Microbiol Infect Dis Date: 2003-05 Impact factor: 2.803

8. The mycotoxins citrinin, gliotoxin, and patulin affect interferon-gamma rather than interleukin-4 production in human blood cells.

Authors: G Wichmann; O Herbarth; I Lehmann
Journal: Environ Toxicol Date: 2002 Impact factor: 4.119

9. Fungal metabolite gliotoxin inhibits assembly of the human respiratory burst NADPH oxidase.

Authors: Shohko Tsunawaki; Lucia S Yoshida; Satoshi Nishida; Toshihiro Kobayashi; Takashi Shimoyama
Journal: Infect Immun Date: 2004-06 Impact factor: 3.441

10. Immunosuppression in vitro by a metabolite of a human pathogenic fungus.

Authors: A Müllbacher; R D Eichner
Journal: Proc Natl Acad Sci U S A Date: 1984-06 Impact factor: 11.205

54 in total

1. LaeA, a regulator of morphogenetic fungal virulence factors.

Authors: Jin Woo Bok; S Arunmozhi Balajee; Kieren A Marr; David Andes; Kristian Fog Nielsen; Jens C Frisvad; Nancy P Keller
Journal: Eukaryot Cell Date: 2005-09

2. Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production.

Authors: Robert A Cramer; Michael P Gamcsik; Rhea M Brooking; Laura K Najvar; William R Kirkpatrick; Thomas F Patterson; Carl J Balibar; John R Graybill; John R Perfect; Soman N Abraham; William J Steinbach
Journal: Eukaryot Cell Date: 2006-06

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Authors: Tobias M Hohl; Marta Feldmesser
Journal: Eukaryot Cell Date: 2007-09-21

4. Mycotoxins in indoor environments.

Authors: H M Ammann
Journal: Mycotoxin Res Date: 2005-09 Impact factor: 3.833

5. A nonredundant role for plasmacytoid dendritic cells in host defense against the human fungal pathogen Aspergillus fumigatus.

Authors: Zaida G Ramirez-Ortiz; Chrono K Lee; Jennifer P Wang; Louis Boon; Charles A Specht; Stuart M Levitz
Journal: Cell Host Microbe Date: 2011-05-19 Impact factor: 21.023

6. Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis.

Authors: Ry R Forseth; Ellen M Fox; DaWoon Chung; Barbara J Howlett; Nancy P Keller; Frank C Schroeder
Journal: J Am Chem Soc Date: 2011-06-06 Impact factor: 15.419