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Literature DB >> 15618201

Development of a chinchilla model to allow direct, continuous, biophotonic imaging of bioluminescent nontypeable Haemophilus influenzae during experimental otitis media.

Laura A Novotny¹, Kevin M Mason, Lauren O Bakaletz.

Abstract

We transformed a nontypeable Haemophilus influenzae clinical isolate with a plasmid containing the luxCDABE operon driven by the H. influenzae outer membrane protein P2 promoter. Herein, we demonstrate the ability to detect bioluminescence and to monitor infection within the nasopharynges, eustachian tubes, and middle ears of chinchillas after intranasal and transbullar challenges.

Entities: Disease Species

Mesh：

Year: 2005 PMID： 15618201 PMCID： PMC538955 DOI： 10.1128/IAI.73.1.609-611.2005

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

11 in total

1. Simultaneous analysis of host and pathogen interactions during an in vivo infection reveals local induction of host acute phase response proteins, a novel bacterial stress response, and evidence of a host-imposed metal ion limited environment.

Authors: S Timothy Motley; Brian J Morrow; Xuejun Liu; Ingrid L Dodge; Antonella Vitiello; Christine K Ward; Karen Joy Shaw
Journal: Cell Microbiol Date: 2004-09 Impact factor: 3.715

2. A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media.

Authors: Kevin M Mason; Robert S Munson; Lauren O Bakaletz
Journal: Infect Immun Date: 2005-01 Impact factor: 3.441

3. Protection against development of otitis media induced by nontypeable Haemophilus influenzae by both active and passive immunization in a chinchilla model of virus-bacterium superinfection.

Authors: L O Bakaletz; B J Kennedy; L A Novotny; G Duquesne; J Cohen; Y Lobet
Journal: Infect Immun Date: 1999-06 Impact factor: 3.441

4. Passive transfer of antiserum specific for immunogens derived from a nontypeable Haemophilus influenzae adhesin and lipoprotein D prevents otitis media after heterologous challenge.

Authors: B J Kennedy; L A Novotny; J A Jurcisek; Y Lobet; L O Bakaletz
Journal: Infect Immun Date: 2000-05 Impact factor: 3.441

5. Synergistic effect of adenovirus type 1 and nontypeable Haemophilus influenzae in a chinchilla model of experimental otitis media.

Authors: K Suzuki; L O Bakaletz
Journal: Infect Immun Date: 1994-05 Impact factor: 3.441

6. Nontypeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media.

Authors: Kevin M Mason; Robert S Munson; Lauren O Bakaletz
Journal: Infect Immun Date: 2003-06 Impact factor: 3.441

7. Simultaneous monitoring of cell number and metabolic activity of specific bacterial populations with a dual gfp-luxAB marker system.

Authors: A Unge; R Tombolini; L Molbak; J K Jansson
Journal: Appl Environ Microbiol Date: 1999-02 Impact factor: 4.792

8. Engineering the luxCDABE genes from Photorhabdus luminescens to provide a bioluminescent reporter for constitutive and promoter probe plasmids and mini-Tn5 constructs.

Authors: M K Winson; S Swift; P J Hill; C M Sims; G Griesmayr; B W Bycroft; P Williams; G S Stewart
Journal: FEMS Microbiol Lett Date: 1998-06-15 Impact factor: 2.742

9. Construction and analysis of luxCDABE-based plasmid sensors for investigating N-acyl homoserine lactone-mediated quorum sensing.

Authors: M K Winson; S Swift; L Fish; J P Throup; F Jørgensen; S R Chhabra; B W Bycroft; P Williams; G S Stewart
Journal: FEMS Microbiol Lett Date: 1998-06-15 Impact factor: 2.742

10. Role of fimbriae expressed by nontypeable Haemophilus influenzae in pathogenesis of and protection against otitis media and relatedness of the fimbrin subunit to outer membrane protein A.

Authors: T Sirakova; P E Kolattukudy; D Murwin; J Billy; E Leake; D Lim; T DeMaria; L Bakaletz
Journal: Infect Immun Date: 1994-05 Impact factor: 3.441

17 in total

Review 1. Noninvasive biophotonic imaging for studies of infectious disease.

Authors: Nuria Andreu; Andrea Zelmer; Siouxsie Wiles
Journal: FEMS Microbiol Rev Date: 2010-10-19 Impact factor: 16.408

Review 2. NAD+ utilization in Pasteurellaceae: simplification of a complex pathway.

Authors: Gabriele Gerlach; Joachim Reidl
Journal: J Bacteriol Date: 2006-10 Impact factor: 3.490

3. A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media.

Authors: Kevin M Mason; Robert S Munson; Lauren O Bakaletz
Journal: Infect Immun Date: 2005-01 Impact factor: 3.441

4. Bacterial sinusitis and otitis media following influenza virus infection in ferrets.

Authors: Ville T Peltola; Kelli L Boyd; Julie L McAuley; Jerold E Rehg; Jonathan A McCullers
Journal: Infect Immun Date: 2006-05 Impact factor: 3.441

5. A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesin.

Authors: James E Bookwalter; Joseph A Jurcisek; Scott D Gray-Owen; Soledad Fernandez; Glen McGillivary; Lauren O Bakaletz
Journal: Infect Immun Date: 2007-10-15 Impact factor: 3.441

6. Nontypeable Haemophilus influenzae releases DNA and DNABII proteins via a T4SS-like complex and ComE of the type IV pilus machinery.

Authors: Joseph A Jurcisek; Kenneth L Brockman; Laura A Novotny; Steven D Goodman; Lauren O Bakaletz
Journal: Proc Natl Acad Sci U S A Date: 2017-07-10 Impact factor: 11.205