Literature DB >> 15617383

Optical detection of thymine dinucleoside monophosphate and its cis-syn photodimer by inorganic nanoparticles.

K K Caswell1, Rahina Mahtab, Catherine J Murphy.   

Abstract

The Watson-Crick DNA double helix is an averaged ideal of multitudinous natural sequence-directed local structural deviations. By effectively derailing normal cellular physiological processes, damaged bases can induce noncanonical irregularities in the local structure of DNA if not efficiently repaired. Pyrimidine bases, especially thymine, are prone to dimerization when exposed to ultraviolet light. A [2 + 2] photocyclo-addition between adjacent thymine bases predominantly produces the cis-syn photodimer. These lesions, implicated in skin cancer, bend DNA by approximately 30 degrees due to their structural and conformational changes. Such changes in molecular properties can be detected by differential quenching of CdS nanoparticle luminescence and by surface-enhanced Raman scattering spectroscopy on metal nanoparticle substrates.

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Year:  2004        PMID： 15617383     DOI： 10.1023/b:jofl.0000031822.12344.84

Source DB:  PubMed          Journal:  J Fluoresc        ISSN： 1053-0509            Impact factor:   2.217


  9 in total

1.  Ultrasensitive chemical analysis by Raman spectroscopy.

Authors:  K Kneipp; H Kneipp; I Itzkan; R R Dasari; M S Feld
Journal:  Chem Rev       Date:  1999-10-13       Impact factor: 60.622

2.  Recognition of hypermethylated triplet repeats in vitro by cationic nanoparticles.

Authors:  L Gearheart; K K Caswell; C J Murphy
Journal:  J Biomed Opt       Date:  2001-04       Impact factor: 3.170

3.  Crystal structure of a DNA decamer containing a cis-syn thymine dimer.

Authors:  HaJeung Park; Kaijiang Zhang; Yingjie Ren; Sourena Nadji; Nanda Sinha; John-Stephen Taylor; ChulHee Kang
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-27       Impact factor: 11.205

4.  Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering

Authors: 
Journal:  Science       Date:  1997-02-21       Impact factor: 47.728

5.  Thymine dimers bend DNA.

Authors:  I Husain; J Griffith; A Sancar
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

6.  Hairpins are formed by the single DNA strands of the fragile X triplet repeats: structure and biological implications.

Authors:  X Chen; S V Mariappan; P Catasti; R Ratliff; R K Moyzis; A Laayoun; S S Smith; E M Bradbury; G Gupta
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-23       Impact factor: 11.205

7.  DNA repeats in the human genome.

Authors:  P Catasti; X Chen; S V Mariappan; E M Bradbury; G Gupta
Journal:  Genetica       Date:  1999       Impact factor: 1.082

8.  Formation of the main UV-induced thymine dimeric lesions within isolated and cellular DNA as measured by high performance liquid chromatography-tandem mass spectrometry.

Authors:  T Douki; M Court; S Sauvaigo; F Odin; J Cadet
Journal:  J Biol Chem       Date:  2000-04-21       Impact factor: 5.157

9.  Nuclear magnetic resonance studies of cis-syn, trans-syn, and 6-4 photodimers of thymidylyl(3'-5')thymidine monophosphate and cis-syn photodimers of thymidylyl(3'-5')thymidine cyanoethyl phosphotriester.

Authors:  L Kan; L Voituriez; J Cadet
Journal:  Biochemistry       Date:  1988-07-26       Impact factor: 3.162
  9 in total

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