Literature DB >> 15616791

Expression pattern of NOGO-A protein in the human nervous system.

A Buss1, B Sellhaus, A Wolmsley, J Noth, M E Schwab, G A Brook.   

Abstract

The distribution pattern of NOGO-A protein, an important axon growth inhibitory molecule and member of the reticulon family, has been investigated in the adult human brain, spinal cord, retina and dorsal root ganglia. Intense NOGO-A immunoreactivity was detected in oligodendroglial cell bodies and their myelin sheaths in nerve fibre tracts of the central nervous system. Furthermore, numerous populations of neurons in the brain and spinal cord expressed NOGO-A to a variable extent in their cell bodies and neurites, suggesting additional, as-yet-unknown, functions of this protein.

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Year:  2004        PMID： 15616791     DOI： 10.1007/s00401-004-0942-z

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  9 in total

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