Literature DB >> 15616328

Interaction of bismuth subsalicylate with fruit juices, ascorbic acid, and thiol-containing substrates to produce soluble bismuth products active against Clostridium difficile.

D E Mahony1, A Woods, M D Eelman, N Burford, S J O Veldhuyzen van Zanten.   

Abstract

Bismuth subsalicylate (BSS), the active ingredient of Pepto-Bismol, has been used for many years to treat various disorders of the gastrointestinal tract. Using mass spectrometry and the agar dilution method, we determined that insoluble BSS interacts with certain dietary components and organic substrates to produce water-soluble products with activity against Clostridium difficile.

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Year:  2005        PMID： 15616328      PMCID： PMC538885          DOI： 10.1128/AAC.49.1.431-433.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Enhancement of bismuth antibacterial activity with lipophilic thiol chelators.

Authors:  P Domenico; R J Salo; S G Novick; P E Schoch; K Van Horn; B A Cunha
Journal:  Antimicrob Agents Chemother       Date:  1997-08       Impact factor: 5.191

2.  The Structurally Flexible Bicyclic Bis(2-hydroxyethanethiolato)bismuth(III) Complex: A Model for Asymmetric Monoanionic Chelation of Bismuth(III).

Authors:  Lisa Agocs; Glen G. Briand; Neil Burford; T. Stanley Cameron; Witold Kwiatkowski; Katherine N. Robertson
Journal:  Inorg Chem       Date:  1997-06-18       Impact factor: 5.165

Review 3.  Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance.

Authors:  U Fuhr
Journal:  Drug Saf       Date:  1998-04       Impact factor: 5.606

Review 4.  Review article: antibiotic-induced Clostridium difficile infection.

Authors:  C D Settle; M H Wilcox
Journal:  Aliment Pharmacol Ther       Date:  1996-12       Impact factor: 8.171

5.  Antimicrobial activities of synthetic bismuth compounds against Clostridium difficile.

Authors:  D E Mahony; S Lim-Morrison; L Bryden; G Faulkner; P S Hoffman; L Agocs; G G Briand; N Burford; H Maguire
Journal:  Antimicrob Agents Chemother       Date:  1999-03       Impact factor: 5.191

6.  Definitive identification of cysteine and glutathione complexes of bismuth by mass spectrometry: assessing the biochemical fate of bismuth pharmaceutical agents.

Authors:  Neil Burford; Melanie D Eelman; David E Mahony; Michael Morash
Journal:  Chem Commun (Camb)       Date:  2003-01-07       Impact factor: 6.222

Review 7.  Grapefruit juice-drug interactions.

Authors:  D G Bailey; J Malcolm; O Arnold; J D Spence
Journal:  Br J Clin Pharmacol       Date:  1998-08       Impact factor: 4.335

8.  Effect of bismuth subsalicylate on Clostridium difficile colitis in hamsters.

Authors:  T W Chang; M Y Dong; S L Gorbach
Journal:  Rev Infect Dis       Date:  1990 Jan-Feb

9.  In vitro antibacterial activity of bismuth subsalicylate.

Authors:  N A Cornick; M Silva; S L Gorbach
Journal:  Rev Infect Dis       Date:  1990 Jan-Feb
  9 in total
  2 in total

1.  The inhibitory effect of colloidal bismuth hydroxide gel on Escherichia coli O157:H7 and on the activity of Shiga toxins.

Authors:  Tomás Subils; Cecilia Casabonne; Claudia Balagué
Journal:  BMC Res Notes       Date:  2014-12-04

2.  Action of Colloidal Bismuth Hydroxide Gel and its Commercial Cream on Enteropathogens and Colonizers of the Gastrointestinal Tract.

Authors:  Tomás Subils; Cecilia Casabonne; Agustina González; Virginia Aquili; Claudia E Balagué
Journal:  J Glob Infect Dis       Date:  2018 Oct-Dec
  2 in total

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