| Literature DB >> 15615511 |
Hongyu Zhao1, Zhili Xin, Gang Liu, Verlyn G Schaefer, H Douglas Falls, Wiweka Kaszubska, Christine A Collins, Hing L Sham.
Abstract
A case study of rational design of an efficient, specific, and proprietary molecular scaffold based on the structure-activity relationship (SAR) information on a screening hit is described. Potent, selective, and orally bioavailable tetralin carboxamide growth hormone secretagogue receptor (GHS-R) antagonists were discovered. Union of rational design and high throughput synthesis provided a quick access to high quality chemical leads.Entities:
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Year: 2004 PMID： 15615511 DOI： 10.1021/jm0491750
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446