Literature DB >> 15614394

Engineering stereocontrol into an aldolase-catalysed reaction.

Henry J Lamble1, Michael J Danson, David W Hough, Steven D Bull.   

Abstract

A novel thermostable aldolase has been developed for synthetic application, and substrate engineering has been used to induce stereocontrol into aldol reactions of this naturally-promiscuous enzyme.

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Year:  2004        PMID： 15614394     DOI： 10.1039/b413255f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  Biochemical and structural exploration of the catalytic capacity of Sulfolobus KDG aldolases.

Authors:  Suzanne Wolterink-van Loo; André van Eerde; Marco A J Siemerink; Jasper Akerboom; Bauke W Dijkstra; John van der Oost
Journal:  Biochem J       Date:  2007-05-01       Impact factor: 3.857

2.  Characterization of l-2-keto-3-deoxyfuconate aldolases in a nonphosphorylating l-fucose metabolism pathway in anaerobic bacteria.

Authors:  Seiya Watanabe
Journal:  J Biol Chem       Date:  2019-12-30       Impact factor: 5.157

3.  Improving low-temperature activity of Sulfolobus acidocaldarius 2-keto-3-deoxygluconate aldolase.

Authors:  Suzanne Wolterink-van Loo; Marco A J Siemerink; Georgios Perrakis; Thijs Kaper; Servé W M Kengen; John van der Oost
Journal:  Archaea       Date:  2009-03-02       Impact factor: 3.273

Review 4.  DHAP-dependent aldolases from (hyper)thermophiles: biochemistry and applications.

Authors:  Pierpaolo Falcicchio; Suzanne Wolterink-Van Loo; Maurice C R Franssen; John van der Oost
Journal:  Extremophiles       Date:  2013-10-29       Impact factor: 2.395

5.  Enzyme catalysis: sweet flexibility.

Authors:  Benjamin G Davis
Journal:  Nat Chem       Date:  2010-02       Impact factor: 24.427

Review 6.  Engineering aldolases as biocatalysts.

Authors:  Claire L Windle; Marion Müller; Adam Nelson; Alan Berry
Journal:  Curr Opin Chem Biol       Date:  2014-01-04       Impact factor: 8.822

7.  Structurally Informed Mutagenesis of a Stereochemically Promiscuous Aldolase Produces Mutants That Catalyze the Diastereoselective Syntheses of All Four Stereoisomers of 3-Deoxy-hexulosonic Acid.

Authors:  Sylvain F Royer; Xuan Gao; Robin R Groleau; Marc W van der Kamp; Steven D Bull; Michael J Danson; Susan J Crennell
Journal:  ACS Catal       Date:  2022-09-06       Impact factor: 13.700
  7 in total

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