BACKGROUND: Epidemiologic studies have reported increases in the incidence of cardiovascular morbidity and myocardial infarction (MI) associated with increases in short-term and daily levels of fine-particulate matter air pollution, suggesting a role for particulate matter in triggering an MI. METHODS: We studied the association between onset time of MI and preceding hourly measures of fine-particulate matter using a case-crossover study of 5793 confirmed cases of acute MI. We linked data from a community-wide database on acute MI from 1988-1994 in King County, Washington, with central site air pollution monitoring data on fine-particulate matter determined by nephelometry. We compared air pollution exposure levels averaged 1 hour, 2 hours, 4 hours, and 24 hours before MI onset to a set of time-stratified referent exposures from the same day of the week in the month of the case event. RESULTS: : The estimated relative risk for a 10-microg/m increase in fine-particulate matter the hour before MI onset was 1.01 (95% CI=0.98-1.05). Analyses of pollutant levels at the other time points demonstrated a similar lack of association. No increased risk was found in all cases with preexisting cardiac disease (odds ratio = 1.05; 0.95-1.16). Stratification by known cardiovascular risk factors (hypertension, diabetes, and smoking status) also did not modify the relation between fine-particulate matter and MI onset. CONCLUSION: Although a very small effect cannot be excluded, there was no consistent association between ambient levels of fine-particulate matter and risk of MI onset.
BACKGROUND: Epidemiologic studies have reported increases in the incidence of cardiovascular morbidity and myocardial infarction (MI) associated with increases in short-term and daily levels of fine-particulate matter air pollution, suggesting a role for particulate matter in triggering an MI. METHODS: We studied the association between onset time of MI and preceding hourly measures of fine-particulate matter using a case-crossover study of 5793 confirmed cases of acute MI. We linked data from a community-wide database on acute MI from 1988-1994 in King County, Washington, with central site air pollution monitoring data on fine-particulate matter determined by nephelometry. We compared air pollution exposure levels averaged 1 hour, 2 hours, 4 hours, and 24 hours before MI onset to a set of time-stratified referent exposures from the same day of the week in the month of the case event. RESULTS: : The estimated relative risk for a 10-microg/m increase in fine-particulate matter the hour before MI onset was 1.01 (95% CI=0.98-1.05). Analyses of pollutant levels at the other time points demonstrated a similar lack of association. No increased risk was found in all cases with preexisting cardiac disease (odds ratio = 1.05; 0.95-1.16). Stratification by known cardiovascular risk factors (hypertension, diabetes, and smoking status) also did not modify the relation between fine-particulate matter and MI onset. CONCLUSION: Although a very small effect cannot be excluded, there was no consistent association between ambient levels of fine-particulate matter and risk of MI onset.
Authors: Robert A Silverman; Kazuhiko Ito; John Freese; Brad J Kaufman; Danilynn De Claro; James Braun; David J Prezant Journal: Am J Epidemiol Date: 2010-08-20 Impact factor: 4.897
Authors: C Ren; A Baccarelli; E Wilker; H Suh; D Sparrow; P Vokonas; R Wright; J Schwartz Journal: J Epidemiol Community Health Date: 2010-01 Impact factor: 3.710
Authors: Niklas Berglind; Petter Ljungman; Jette Möller; Johan Hallqvist; Fredrik Nyberg; Mårten Rosenqvist; Göran Pershagen; Tom Bellander Journal: Int J Environ Res Public Health Date: 2010-03-31 Impact factor: 3.390
Authors: David Q Rich; Howard M Kipen; Junfeng Zhang; Leena Kamat; Alan C Wilson; John B Kostis Journal: Environ Health Perspect Date: 2010-04-30 Impact factor: 9.031