R W I Cooke1. 1. Department of Child Health, University of Liverpool, Neonatal Unit, Liverpool Maternity Hospital, Liverpool L8 7SS, UK. mc19@liv.ac.uk
Abstract
BACKGROUND: Many children born very preterm have cognitive and minor motor problems later, even if attending mainstream schools. OBJECTIVE: To examine associations between this suboptimal performance and perinatal and postnatal clinical factors. PARTICIPANTS AND METHODS: A geographically determined cohort of 280 infants born at less than 32 weeks gestation in 1991-92 in Liverpool, free of major disability and attending mainstream school at 7 years of age. A perinatal and postnatal data set were obtained from the clinical records retrospectively. Measurements of height, weight, and head circumference at 7 years were made, together with assessments of intelligence (Wechsler intelligence scale for children, IQ) and motor impairment (Movement assessment battery for children, MABC). RESULTS: Multiple regression analysis showed IQ at 7 years to be independently significantly related to gestation, persistence of the arterial duct (PDA), and head circumference at 7 years. MABC was only significantly related to gestation. PDA was related to periventricular haemorrhage (OR 2.7, 95% confidence interval (CI) 1.3 to 5.8) and parenchymal lesions including ventriculomegaly (OR 4.1, 95% CI 1.5 to 11.4). CONCLUSION: Cognitive ability in children born preterm is significantly related to gestation, but may also be related to the effects of PDA on early brain development, through either periventricular haemorrhage/ventriculomegaly or other disturbance of early brain growth.
BACKGROUND: Many children born very preterm have cognitive and minor motor problems later, even if attending mainstream schools. OBJECTIVE: To examine associations between this suboptimal performance and perinatal and postnatal clinical factors. PARTICIPANTS AND METHODS: A geographically determined cohort of 280 infants born at less than 32 weeks gestation in 1991-92 in Liverpool, free of major disability and attending mainstream school at 7 years of age. A perinatal and postnatal data set were obtained from the clinical records retrospectively. Measurements of height, weight, and head circumference at 7 years were made, together with assessments of intelligence (Wechsler intelligence scale for children, IQ) and motor impairment (Movement assessment battery for children, MABC). RESULTS: Multiple regression analysis showed IQ at 7 years to be independently significantly related to gestation, persistence of the arterial duct (PDA), and head circumference at 7 years. MABC was only significantly related to gestation. PDA was related to periventricular haemorrhage (OR 2.7, 95% confidence interval (CI) 1.3 to 5.8) and parenchymal lesions including ventriculomegaly (OR 4.1, 95% CI 1.5 to 11.4). CONCLUSION: Cognitive ability in children born preterm is significantly related to gestation, but may also be related to the effects of PDA on early brain development, through either periventricular haemorrhage/ventriculomegaly or other disturbance of early brain growth.
Authors: B Schmidt; P Davis; D Moddemann; A Ohlsson; R S Roberts; S Saigal; A Solimano; M Vincer; L L Wright Journal: N Engl J Med Date: 2001-06-28 Impact factor: 91.245
Authors: Rula Nassar; Antonia N Kaczkurkin; Cedric Huchuan Xia; Aristeidis Sotiras; Marieta Pehlivanova; Tyler M Moore; Angel Garcia de La Garza; David R Roalf; Adon F G Rosen; Scott A Lorch; Kosha Ruparel; Russell T Shinohara; Christos Davatzikos; Ruben C Gur; Raquel E Gur; Theodore D Satterthwaite Journal: Cereb Cortex Date: 2019-05-01 Impact factor: 5.357