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Literature DB >> 15613362

Relevance of apoptin's integrity for its functional behavior.

J L Rohn, Y-H Zhang, S R Leliveld, A A A M Danen-van Oorschot, N V Henriquez, J P Abrahams, M H M Noteborn.

Abstract

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Year: 2005 PMID： 15613362 PMCID： PMC538565 DOI： 10.1128/JVI.79.2.1337-1338.2005

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

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9 in total

1. Apoptin induces tumor-specific apoptosis as a globular multimer.

Authors: Sirik R Leliveld; Ying-Hui Zhang; Jennifer L Rohn; Mathieu H M Noteborn; Jan Pieter Abrahams
Journal: J Biol Chem Date: 2002-12-19 Impact factor: 5.157

2. Apoptin/VP3 contains a concentration-dependent nuclear localization signal (NLS), not a tumorigenic selective NLS.

Authors: J S Wadia; M V Wagner; S A Ezhevsky; S F Dowdy
Journal: J Virol Date: 2004-06 Impact factor: 5.103

3. Recombinant Apoptin multimers kill tumor cells but are nontoxic and epitope-shielded in a normal-cell-specific fashion.

Authors: Ying Hui Zhang; S Rutger Leliveld; Klaas Kooistra; Chris Molenaar; Jennifer L Rohn; Hans J Tanke; Jan Pieter Abrahams; Mathieu H M Noteborn
Journal: Exp Cell Res Date: 2003-09-10 Impact factor: 3.905

4. Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells.

Authors: A A Danen-Van Oorschot; D F Fischer; J M Grimbergen; B Klein; S Zhuang; J H Falkenburg; C Backendorf; P H Quax; A J Van der Eb; M H Noteborn
Journal: Proc Natl Acad Sci U S A Date: 1997-05-27 Impact factor: 11.205

5. Activation of the tumor-specific death effector apoptin and its kinase by an N-terminal determinant of simian virus 40 large T antigen.

Authors: Ying-Hui Zhang; Klaas Kooistra; Alexandra Pietersen; Jennifer L Rohn; Mathieu H M Noteborn
Journal: J Virol Date: 2004-09 Impact factor: 5.103

6. The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin-interacting protein 1.

Authors: Chih-Mei Cheng; Shiao-ping Huang; Yung-Fu Chang; Wen-Yuan Chung; Chung-Yee Yuo
Journal: Biochem Biophys Res Commun Date: 2003-05-30 Impact factor: 3.575

7. Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis.

Authors: Astrid A A M Danen-Van Oorschot; Ying-Hui Zhang; S Rutger Leliveld; Jennifer L Rohn; Maud C M J Seelen; Marian W Bolk; Arend Van Zon; Stefan J Erkeland; Jan-Pieter Abrahams; Dominik Mumberg; Mathieu H M Noteborn
Journal: J Biol Chem Date: 2003-05-16 Impact factor: 5.157

8. A tumor-specific kinase activity regulates the viral death protein Apoptin.

Authors: Jennifer L Rohn; Ying-Hui Zhang; Remco I J M Aalbers; Norbert Otto; Jeroen Den Hertog; Niek V Henriquez; Cornelis J H Van De Velde; Peter J K Kuppen; Dominik Mumberg; Peter Donner; Mathieu H M Noteborn
Journal: J Biol Chem Date: 2002-10-21 Impact factor: 5.157

9. TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.

Authors: Lars Guelen; Hugh Paterson; Joop Gäken; Michelle Meyers; Farzin Farzaneh; Mahvash Tavassoli
Journal: Oncogene Date: 2004-02-05 Impact factor: 9.867

9 in total

1. Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/cyclosome to PML bodies.

Authors: Destin W Heilman; Jose G Teodoro; Michael R Green
Journal: J Virol Date: 2006-08 Impact factor: 5.103

Relevance of apoptin's integrity for its functional behavior.

1. Apoptin induces tumor-specific apoptosis as a globular multimer.

2. Apoptin/VP3 contains a concentration-dependent nuclear localization signal (NLS), not a tumorigenic selective NLS.

3. Recombinant Apoptin multimers kill tumor cells but are nontoxic and epitope-shielded in a normal-cell-specific fashion.

4. Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells.

5. Activation of the tumor-specific death effector apoptin and its kinase by an N-terminal determinant of simian virus 40 large T antigen.

6. The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin-interacting protein 1.

7. Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis.

8. A tumor-specific kinase activity regulates the viral death protein Apoptin.

9. TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.

1. Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/cyclosome to PML bodies.

2. A truncated apoptin protein variant selectively kills cancer cells.

Review 3. Viral genes as oncolytic agents for cancer therapy.

4. Human-gyrovirus-Apoptin triggers mitochondrial death pathway--Nur77 is required for apoptosis triggering.

5. Enhanced tumour cell nuclear targeting in a tumour progression model.

6. C-terminal region of apoptin affects chicken anemia virus replication and virulence.

Review 7. The Role of Apoptin in Chicken Anemia Virus Replication.

Review 8. Cancer Treatment Goes Viral: Using Viral Proteins to Induce Tumour-Specific Cell Death.

Review 9. Apoptosis Triggered by ORF3 Proteins of the Circoviridae Family.