Literature DB >> 15610844

Sequence-selective DNA recognition: natural products and nature's lessons.

Winston C Tse1, Dale L Boger.   

Abstract

Biologically active, therapeutically useful, DNA binding natural products continue to reveal new paradigms for sequence-selective recognition, to enlist beautiful mechanisms of in situ activation for DNA modification, to define new therapeutic targets, to exploit new mechanisms to achieve cellular selectivity, and to provide a rich source of new drugs. These attributes arise in compact structures of complex integrated function.

Mesh:

Substances:

Year:  2004        PMID: 15610844     DOI: 10.1016/j.chembiol.2003.08.012

Source DB:  PubMed          Journal:  Chem Biol        ISSN: 1074-5521


  72 in total

1.  Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator.

Authors:  Mostafa I Fekry; Jozsef Szekely; Sanjay Dutta; Leonid Breydo; Hong Zang; Kent S Gates
Journal:  J Am Chem Soc       Date:  2011-10-18       Impact factor: 15.419

2.  Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit.

Authors:  Kristopher E Boyle; Karen S MacMillan; David A Ellis; James P Lajiness; William M Robertson; Dale L Boger
Journal:  Bioorg Med Chem Lett       Date:  2010-02-02       Impact factor: 2.823

3.  Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity.

Authors:  Mark S Tichenor; Karen S MacMillan; John D Trzupek; Thomas J Rayl; Inkyu Hwang; Dale L Boger
Journal:  J Am Chem Soc       Date:  2007-08-11       Impact factor: 15.419

4.  Discovery of inhibitors of aberrant gene transcription from Libraries of DNA binding molecules: inhibition of LEF-1-mediated gene transcription and oncogenic transformation.

Authors:  James S Stover; Jin Shi; Wei Jin; Peter K Vogt; Dale L Boger
Journal:  J Am Chem Soc       Date:  2009-03-11       Impact factor: 15.419

5.  The Mechanism of Action of (-)-Lomaiviticin A.

Authors:  Seth B Herzon
Journal:  Acc Chem Res       Date:  2017-09-28       Impact factor: 22.384

6.  A five-membered lactone prodrug of CBI-based analogs of the duocarmycins.

Authors:  Mika Uematsu; Daniel M Brody; Dale L Boger
Journal:  Tetrahedron Lett       Date:  2015-06-03       Impact factor: 2.415

7.  Synthesis and DNA binding profile of N-mono- and N,N'-disubstituted indolo[3,2-b]carbazoles.

Authors:  Harmanpreet Kaur Panesar; Jennifer Solano; Thomas G Minehan
Journal:  Org Biomol Chem       Date:  2015-03-14       Impact factor: 3.876

8.  Dimeric and trimeric derivatives of the azinomycin B chromophore show enhanced DNA binding.

Authors:  Milena Balazy; Alejandra Fausto; Christina Voskanian; Bianca Chavez; Harmanpreet Panesar; Thomas G Minehan
Journal:  Org Biomol Chem       Date:  2017-05-31       Impact factor: 3.876

9.  Entering the leinamycin rearrangement via 2-(trimethylsilyl)ethyl sulfoxides.

Authors:  Kripa Keerthi; Kent S Gates
Journal:  Org Biomol Chem       Date:  2007-04-13       Impact factor: 3.876

10.  Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents.

Authors:  Karita Peltonen; Laureen Colis; Hester Liu; Sari Jäämaa; Henna M Moore; Juulia Enbäck; Pirjo Laakkonen; Anne Vaahtokari; Richard J Jones; Taija M af Hällström; Marikki Laiho
Journal:  PLoS One       Date:  2010-09-27       Impact factor: 3.240

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.