Literature DB >> 15610772

Automated assays to study longevity in C. elegans.

Maren Hertweck1, Ralf Baumeister.   

Abstract

The nematode Caenorhabditis elegans is excellently suited as a model for studying the genetic and molecular genetic basis of aging, and to test chemical compounds that interfere with the aging process. Mutants of factors in both the insulin and target of rapamycin (TOR) signalling pathways have been shown to extend life span of the worm. Phenotypic similarities among those mutants suggested that, exploiting the corresponding phenotypes in a semiautomated way, may increase the speed of investigating life span and aging in C. elegans. Here, we discuss several methodological approaches to automate longevity assays in the nematode.

Entities:  

Mesh：

Year:  2005        PMID： 15610772     DOI： 10.1016/j.mad.2004.09.010

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN： 0047-6374            Impact factor:   5.432


  10 in total

Review 1.  Multiplexed and microparticle-based analyses: quantitative tools for the large-scale analysis of biological systems.

Authors:  John P Nolan; Francis Mandy
Journal:  Cytometry A       Date:  2006-05       Impact factor: 4.355

2.  Pharmacological intervention in invertebrate aging.

Authors:  Gordon J Lithgow; Matthew S Gill; Anders Olsen; James N Sampayo
Journal:  Age (Dordr)       Date:  2005-12-31

Review 3.  Function, Regulation, and Pathophysiological Relevance of the POT Superfamily, Specifically PepT1 in Inflammatory Bowel Disease.

Authors:  Emilie Viennois; Adani Pujada; Jane Zen; Didier Merlin
Journal:  Compr Physiol       Date:  2018-03-25       Impact factor: 9.090

4.  Extended Twilight among Isogenic C. elegans Causes a Disproportionate Scaling between Lifespan and Health.

Authors:  William B Zhang; Drew B Sinha; William E Pittman; Erik Hvatum; Nicholas Stroustrup; Zachary Pincus
Journal:  Cell Syst       Date:  2016-10-06       Impact factor: 10.304

5.  Spectral measurements of large particles by flow cytometry.

Authors:  Dakota A Watson; Daniel F Gaskill; Leif O Brown; Stephen K Doorn; John P Nolan
Journal:  Cytometry A       Date:  2009-05       Impact factor: 4.355

6.  Active backlight for automating visual monitoring: An analysis of a lighting control technique for Caenorhabditis elegans cultured on standard Petri plates.

Authors:  Joan Carles Puchalt; Antonio-José Sánchez-Salmerón; Patricia Martorell Guerola; Salvador Genovés Martínez
Journal:  PLoS One       Date:  2019-04-16       Impact factor: 3.240

7.  Small flexible automated system for monitoring Caenorhabditis elegans lifespan based on active vision and image processing techniques.

Authors:  Joan Carles Puchalt; Antonio-José Sánchez-Salmerón; Eugenio Ivorra; Silvia Llopis; Roberto Martínez; Patricia Martorell
Journal:  Sci Rep       Date:  2021-06-10       Impact factor: 4.379

8.  Using Multiple Phenotype Assays and Epistasis Testing to Enhance the Reliability of RNAi Screening and Identify Regulators of Muscle Protein Degradation.

Authors:  Susann Lehmann; Freya Shephard; Lewis A Jacobson; Nathaniel J Szewczyk
Journal:  Genes (Basel)       Date:  2012-11-02       Impact factor: 4.096

9.  Multiview motion tracking based on a cartesian robot to monitor Caenorhabditis elegans in standard Petri dishes.

Authors:  Joan Carles Puchalt; Jose F Gonzalez-Rojo; Ana Pilar Gómez-Escribano; Rafael P Vázquez-Manrique; Antonio-José Sánchez-Salmerón
Journal:  Sci Rep       Date:  2022-02-02       Impact factor: 4.379

10.  Rapid counting and spectral sorting of live coral larvae using large-particle flow cytometry.

Authors:  Carly J Randall; Justin E Speaks; Claire Lager; Mary Hagedorn; Lyndon Llewellyn; Rock Pulak; Julia Thompson; Line K Bay; David Mead; Andrew J Heyward; Andrew P Negri
Journal:  Sci Rep       Date:  2020-07-31       Impact factor: 4.996
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.