P Tiilikainen1, P Pirttiniemi, T Kainulainen, H Pernu, A Raustia. 1. Department of Prosthetic Dentistry and Stomatognathic Physiology, Institute of Dentistry, University of Oulu and Oulu University Hospital, Finland. petri.tiilikainen@oulu.fi
Abstract
BACKGROUND: Internal derangement is one of the most common disorder of the temporomandibular joint (TMJ). The aim of this study was to investigate the associations of matrix metalloproteinase (MMP)-3 and -8 expression in articular condylar surface with different stages of TMJ internal derangement according to Wilkes (Minn Med, 1978; 61: 645-52) and osteoarthrosis (OA) according to Dijkgraaf et al. (J Oral Maxillofac Surg, 1995; 53: 1182-92). METHODS: The study was based on 54 condylar specimens obtained during TMJ surgery. Immunohistochemistry using antibodies specific to MMP-3 and -8, represented in cartilage destruction, was carried out. RESULTS: In all tissue specimens, MMP-3 expression was intense in the surface layer but showed less intensive staining in the deeper layers. Some MMP-8 expression was also seen. The severity of TMJ internal derangement, however, did not seem to have a statistically significant correlation (P<0.05) with the expression of these enzymes. CONCLUSION: The study confirms that distinct expression of MMP-3 and -8 is found in the condylar surface of TMJs with internal derangement.
BACKGROUND: Internal derangement is one of the most common disorder of the temporomandibular joint (TMJ). The aim of this study was to investigate the associations of matrix metalloproteinase (MMP)-3 and -8 expression in articular condylar surface with different stages of TMJ internal derangement according to Wilkes (Minn Med, 1978; 61: 645-52) and osteoarthrosis (OA) according to Dijkgraaf et al. (J Oral Maxillofac Surg, 1995; 53: 1182-92). METHODS: The study was based on 54 condylar specimens obtained during TMJ surgery. Immunohistochemistry using antibodies specific to MMP-3 and -8, represented in cartilage destruction, was carried out. RESULTS: In all tissue specimens, MMP-3 expression was intense in the surface layer but showed less intensive staining in the deeper layers. Some MMP-8 expression was also seen. The severity of TMJ internal derangement, however, did not seem to have a statistically significant correlation (P<0.05) with the expression of these enzymes. CONCLUSION: The study confirms that distinct expression of MMP-3 and -8 is found in the condylar surface of TMJs with internal derangement.
Authors: Christopher Phillip Chen; Jiehua Zhang; Bin Zhang; Mohamed G Hassan; Kyle Hane; Caroline C Chen; Ana Alejandra Navarro Palacios; Sunil Kapila; Andrew H Jheon; Alice F Goodwin Journal: JBMR Plus Date: 2022-07-03