| Literature DB >> 15609849 |
V A Mironov, O V Sergienko, I N Nastasiak, V N Danilenko.
Abstract
Data on the structure and stages of biosynthesis of erythromycins, relating to (1) successive addition of L-mycarose and D-desosamine to the lactones erythronolide B and mycarosyl-erythronolide B, respectively, and (2) biotransformation of erythromycin D to erythromycin A, are presented. Pathways of biosynthesis of L-mycarose, D-desosamine, and methylmalonyl-CoA and methylpropionyl-CoA precursors of erythronolide B are reviewed, along with the properties of genes coding the enzymes involved. Possible mechanisms of biochemical and gene regulation of erythromycin biosynthesis in Saccharopolyspora erythraea are discussed, including the role of factors ensuring predominant formation of the target product, erythromycin A.Entities:
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Year: 2004 PMID： 15609849
Source DB: PubMed Journal: Prikl Biokhim Mikrobiol ISSN： 0555-1099