Literature DB >> 15609242

Influence of indinavir on virulence and growth of Cryptococcus neoformans.

Claudia Monari1, Eva Pericolini, Giovanni Bistoni, Elio Cenci, Francesco Bistoni, Anna Vecchiarelli.   

Abstract

Indinavir selectively inhibited production of some virulence factors of Cryptococcus neoformans, such as urease and protease, but not melanin and phospholipase; moreover, it interfered with capsule formation. These effects led to increased susceptibility of C. neoformans to intracellular killing by natural effector cells. Prolonged incubation with indinavir resulted in inhibition of fungal growth. Indinavir can attenuate the virulence of the fungus, thus augmenting its susceptibility to the antimicrobial activity of natural effector cells. The reduction in cryptococcal infections in human immunodeficiency virus-positive patients might also be related to the antifungal activity of highly active antiretroviral therapy.

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Year:  2004        PMID： 15609242     DOI： 10.1086/426828

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

Review 1.  Phagocytic activity in human immunodeficiency virus type 1 infection.

Authors:  Agostino Pugliese; Valerio Vidotto; Tiziana Beltramo; Donato Torre
Journal:  Clin Diagn Lab Immunol       Date:  2005-08

2.  Repression of Proteases and Hsp90 Chaperone Expression Induced by an Antiretroviral in Virulent Environmental Strains of Cryptococcus neoformans.

Authors:  Cleber Fernando Serafin; Ana Paula Paris; Claudete Rodrigues Paula; Rita Cássia Garcia Simão; Rinaldo Ferreira Gandra
Journal:  Microb Ecol       Date:  2016-12-02       Impact factor: 4.552

3.  Antiretroviral Therapy Administration in Healthy Rhesus Macaques Is Associated with Transient Shifts in Intestinal Bacterial Diversity and Modest Immunological Perturbations.

Authors:  Alexandra M Ortiz; Jacob K Flynn; Sarah R DiNapoli; Ornella Sortino; Ivan Vujkovic-Cvijin; Yasmine Belkaid; Irini Sereti; Jason M Brenchley
Journal:  J Virol       Date:  2019-08-28       Impact factor: 5.103

Review 4.  Cryptococcal therapies and drug targets: the old, the new and the promising.

Authors:  Carolina Coelho; Arturo Casadevall
Journal:  Cell Microbiol       Date:  2016-04-08       Impact factor: 3.715

5.  Involvement of glycoreceptors in galactoxylomannan-induced T cell death.

Authors:  Eva Pericolini; Elena Gabrielli; Elio Cenci; Magdia De Jesus; Francesco Bistoni; Arturo Casadevall; Anna Vecchiarelli
Journal:  J Immunol       Date:  2009-05-15       Impact factor: 5.422

6.  Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner.

Authors:  Camile P Semighini; Anna F Averette; John R Perfect; Joseph Heitman
Journal:  PLoS Pathog       Date:  2011-11-17       Impact factor: 6.823

7.  Repositioning Lopinavir, an HIV Protease Inhibitor, as a Promising Antifungal Drug: Lessons Learned from Candida albicans-In Silico, In Vitro and In Vivo Approaches.

Authors:  André L S Santos; Lys A Braga-Silva; Diego S Gonçalves; Lívia S Ramos; Simone S C Oliveira; Lucieri O P Souza; Vanessa S Oliveira; Roberto D Lins; Marcia R Pinto; Julian E Muñoz; Carlos P Taborda; Marta H Branquinha
Journal:  J Fungi (Basel)       Date:  2021-05-28

8.  Nelfinavir is effective in inhibiting the multiplication and aspartic peptidase activity of Leishmania species, including strains obtained from HIV-positive patients.

Authors:  Lívia O Santos; Bianca S Vitório; Marta H Branquinha; Conceição M Pedroso e Silva; André L S Santos; Claudia M d'Avila-Levy
Journal:  J Antimicrob Chemother       Date:  2012-10-28       Impact factor: 5.790

9.  Beneficial effects of HIV peptidase inhibitors on Fonsecaea pedrosoi: promising compounds to arrest key fungal biological processes and virulence.

Authors:  Vanila F Palmeira; Lucimar F Kneipp; Sonia Rozental; Celuta S Alviano; André L S Santos
Journal:  PLoS One       Date:  2008-10-13       Impact factor: 3.240

10.  HIV aspartyl peptidase inhibitors interfere with cellular proliferation, ultrastructure and macrophage infection of Leishmania amazonensis.

Authors:  Lívia O Santos; Fernanda A Marinho; Ellen F Altoé; Bianca S Vitório; Carlos R Alves; Constança Britto; Maria Cristina M Motta; Marta H Branquinha; André L S Santos; Claudia M d'Avila-Levy
Journal:  PLoS One       Date:  2009-03-26       Impact factor: 3.240
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