Literature DB >> 15609101

Estrogen receptor alpha expression in mice kidney shows sex differences during aging.

P K Sharma1, M K Thakur.   

Abstract

We have used semi quantitative RT-PCR and western blotting for the analysis of expression of estrogen receptor (ER) alpha and beta mRNA and protein in the kidney of adult and old mice of both sexes. Uterus, a well-known target for estrogen action, was used for comparison. As compared to adult, the expression of both ER alpha mRNA and protein of old mice decreased in male but increased in female. However, unlike uterus, neither ERbeta mRNA nor protein could be detected in the kidney of adult or old mice. Thus the present data reveal that the expression of ERalpha in mice kidney shows sex differences during aging.

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Year:  2004        PMID： 15609101     DOI： 10.1007/s10522-004-3191-6

Source DB:  PubMed          Journal:  Biogerontology        ISSN： 1389-5729            Impact factor:   4.277


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