Heather Yeo1, Sanziana Roman. 1. Department of General Surgery, Yale University School of Medicine, New Haven, CT 06520, USA.
Abstract
PURPOSE OF REVIEW: Pheochromocytoma is a rare, but clinically important tumor of chromaffin cells. Advances in our understanding of the genetic alterations causing hereditary forms and the increasing sensitivity of biochemical assays allow for early identification of high risk individuals and families. Surgical intervention remains the treatment of choice for patients with pheochromocytoma. This article reviews recent developments in the diagnosis, treatment, and pathophysiology of pheochromocytoma, with the objective of developing new guidelines in the identification and management of the disease. It emphasizes current diagnostic and surgical approaches and discusses the potential for future developments in the field. SUMMARY: Advances in the molecular basis of pheochromocytoma have introduced new diagnostic modalities. Refinements in imaging techniques have improved the rate of detection of metastatic disease. Innovations in surgical techniques and trials of adrenal sparing surgery may find a niche in the surgical armamentarium.
PURPOSE OF REVIEW: Pheochromocytoma is a rare, but clinically important tumor of chromaffin cells. Advances in our understanding of the genetic alterations causing hereditary forms and the increasing sensitivity of biochemical assays allow for early identification of high risk individuals and families. Surgical intervention remains the treatment of choice for patients with pheochromocytoma. This article reviews recent developments in the diagnosis, treatment, and pathophysiology of pheochromocytoma, with the objective of developing new guidelines in the identification and management of the disease. It emphasizes current diagnostic and surgical approaches and discusses the potential for future developments in the field. SUMMARY: Advances in the molecular basis of pheochromocytoma have introduced new diagnostic modalities. Refinements in imaging techniques have improved the rate of detection of metastatic disease. Innovations in surgical techniques and trials of adrenal sparing surgery may find a niche in the surgical armamentarium.
Authors: Katharina Maria Bretterbauer; Daniela Colleselli; Ahmed Magdy; Günter Janetschek; Michael Mitterberger Journal: Wien Med Wochenschr Date: 2015-07-14
Authors: Dario Cotesta; Luigi Petramala; Valentina Serra; Mario Pergolini; Eleonora Crescenzi; Laura Zinnamosca; Giorgio De Toma; Antonio Ciardi; Iacopo Carbone; Rita Massa; Sebastiano Filetti; Claudio Letizia Journal: High Blood Press Cardiovasc Prev Date: 2013-01-03
Authors: Gonca Kara Gedik; Cornelis A Hoefnagel; Evert Bais; Renato A Valdés Olmos Journal: Eur J Nucl Med Mol Imaging Date: 2007-12-11 Impact factor: 9.236