OBJECTIVES: To investigate the markers of endogenous coagulation/fibrinolysis and vascular endothelial cell function, and to assess the relationships between hemostatic parameters and diabetic vascular complications in type 2 diabetic patients. MATERIALS AND METHODS: Coagulation and fibrinolysis parameters were measured in 92 type 2 diabetic patients (43 male, 49 female, mean age 50.1 +/- 13.4 years) with (n = 44) and without (n = 48) vascular diabetic complications, and in 40 nondiabetic healthy subjects (20 male, 20 female, mean age 49.8 +/- 15.1 years). Common lipid parameters were also measured. RESULTS: The plasma levels of fibrinogen, antithrombin III (AT III), plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (vWF) activity and prothrombin time were found to be significantly increased in the type 2 diabetic patients compared with the healthy subjects. Glycosylated hemoglobin lc was inversely correlated with plasma protein S and activated prothrombin time. Protein C and S activities were positively correlated with plasma vWF activity, and were negatively correlated with plasma t-PA levels. vWF activity was negatively correlated with plasma t-PA levels. AT III levels were positively correlated with plasma total cholesterol levels, plasma low density lipoprotein cholesterol levels, plasma triglycerides and D-dimer levels. Plasma PAI-1 levels and factor V activity in diabetic patients with microvascular complications were significantly higher than those of the diabetic patients without microvascular complications. The plasma PAI-1 and platelet count were increased in patients with diabetic retinopathy compared with the diabetic patients without retinopathy. Plasma PAI-1 levels and factor VII activity were significantly higher in the diabetic patients with nephropathy than in diabetic patients without nephropathy. Plasma concentrations of fibrinogen and PAI-1 were significantly higher in the diabetic patients with neuropathy than the diabetic patients without neuropathy. CONCLUSIONS: The data demonstrated that patients with type 2 diabetes mellitus had a hypercoagulable state and hypofibrinolysis, thereby indicating that activation of coagulation with a reduced fibrinolytic activity may contribute to the increased risk of vascular disease in type 2 diabetic patients.
OBJECTIVES: To investigate the markers of endogenous coagulation/fibrinolysis and vascular endothelial cell function, and to assess the relationships between hemostatic parameters and diabetic vascular complications in type 2 diabeticpatients. MATERIALS AND METHODS: Coagulation and fibrinolysis parameters were measured in 92 type 2 diabeticpatients (43 male, 49 female, mean age 50.1 +/- 13.4 years) with (n = 44) and without (n = 48) vascular diabetic complications, and in 40 nondiabetic healthy subjects (20 male, 20 female, mean age 49.8 +/- 15.1 years). Common lipid parameters were also measured. RESULTS: The plasma levels of fibrinogen, antithrombin III (AT III), plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (vWF) activity and prothrombin time were found to be significantly increased in the type 2 diabeticpatients compared with the healthy subjects. Glycosylated hemoglobin lc was inversely correlated with plasma protein S and activated prothrombin time. Protein C and S activities were positively correlated with plasma vWF activity, and were negatively correlated with plasma t-PA levels. vWF activity was negatively correlated with plasma t-PA levels. AT III levels were positively correlated with plasma total cholesterol levels, plasma low density lipoprotein cholesterol levels, plasma triglycerides and D-dimer levels. Plasma PAI-1 levels and factor V activity in diabeticpatients with microvascular complications were significantly higher than those of the diabeticpatients without microvascular complications. The plasma PAI-1 and platelet count were increased in patients with diabetic retinopathy compared with the diabeticpatients without retinopathy. Plasma PAI-1 levels and factor VII activity were significantly higher in the diabeticpatients with nephropathy than in diabeticpatients without nephropathy. Plasma concentrations of fibrinogen and PAI-1 were significantly higher in the diabeticpatients with neuropathy than the diabeticpatients without neuropathy. CONCLUSIONS: The data demonstrated that patients with type 2 diabetes mellitus had a hypercoagulable state and hypofibrinolysis, thereby indicating that activation of coagulation with a reduced fibrinolytic activity may contribute to the increased risk of vascular disease in type 2 diabeticpatients.
Authors: Hussein A Rajab; Nathaniel L Baker; Kelly J Hunt; Richard Klein; Patricia A Cleary; John Lachin; Gabriel Virella; Maria F Lopes-Virella Journal: J Diabetes Complications Date: 2014-08-20 Impact factor: 2.852
Authors: M Erdogan; S Solmaz; A Canataroglu; M Kulaksızoglu; S Cetinkalp; A G Ozgen; F Saygili; C Yilmaz Journal: Endocrine Date: 2010-04-14 Impact factor: 3.633
Authors: Rozalina G McCoy; Brian A Irving; Mattias Soop; Manivanan Srinivasan; Laura Tatpati; Lisa Chow; Audrey J Weymiller; Rickey E Carter; K Sreekumaran Nair Journal: Mayo Clin Proc Date: 2012-06 Impact factor: 7.616
Authors: Kubilay Ukinc; Halil Onder Ersoz; Cihangir Erem; Arif Bayram Hacihasanoglu; Suleyman Sami Karti Journal: Endocrine Date: 2009-03-04 Impact factor: 3.633
Authors: Richard Kd Ephraim; Yaw A Awuku; Patrick Adu; Lord Tw Ampomah; Prince Adoba; Solomon Panford; Jerry Pk Ninnoni; Hope Agbodzakey Journal: Ghana Med J Date: 2017-09
Authors: Thanh T Nguyen; Ekaterina Alibrahim; F M Amirul Islam; Ronald Klein; Barbara E K Klein; Mary Frances Cotch; Steven Shea; Tien Y Wong Journal: Diabetes Care Date: 2009-06-23 Impact factor: 19.112