Literature DB >> 15607482

Simplified PET measurement for evaluating histamine H1 receptors in human brains using [11C]doxepin.

Hideki Mochizuki1, Yuichi Kimura, Kenji Ishii, Keiichi Oda, Toru Sasaki, Manabu Tashiro, Kazuhiko Yanai, Kiichi Ishiwata.   

Abstract

The aim of this study was to develop simplified positron emission tomography measurement using [(11)C]doxepin ([(11)C]DOX) to evaluate histamine H(1) receptors (H1Rs) in human brains. We evaluated the correlation between the distribution volume (DV) of [(11)C]DOX, estimated quantitatively with a two-compartment model, and the [(11)C]DOX uptake obtained at various time intervals and normalized using the metabolite-corrected plasma radioactivity. We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [(11)C]DOX-H1R binding.

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Year:  2004        PMID： 15607482     DOI： 10.1016/j.nucmedbio.2004.06.009

Source DB:  PubMed          Journal:  Nucl Med Biol        ISSN： 0969-8051            Impact factor:   2.408


  6 in total

1.  Brain histamine H receptor occupancy of orally administered antihistamines measured by positron emission tomography with (11)C-doxepin in a placebo-controlled crossover study design in healthy subjects: a comparison of olopatadine and ketotifen.

Authors:  Manabu Tashiro; Hideki Mochizuki; Yumiko Sakurada; Kenji Ishii; Keiichi Oda; Yuichi Kimura; Toru Sasaki; Kiichi Ishiwata; Kazuhiko Yanai
Journal:  Br J Clin Pharmacol       Date:  2006-01       Impact factor: 4.335

2.  Histamine H1 receptor occupancy by the new-generation antipsychotics olanzapine and quetiapine: a positron emission tomography study in healthy volunteers.

Authors:  Hirotoshi Sato; Chihiro Ito; Kotaro Hiraoka; Manabu Tashiro; Katsuhiko Shibuya; Yoshihito Funaki; Takeo Yoshikawa; Ren Iwata; Hiroo Matsuoka; Kazuhiko Yanai
Journal:  Psychopharmacology (Berl)       Date:  2015-07-07       Impact factor: 4.530

3.  Brain histamine H1 receptor occupancy of orally administered antihistamines, bepotastine and diphenhydramine, measured by PET with 11C-doxepin.

Authors:  Manabu Tashiro; Xudong Duan; Motohisa Kato; Masayasu Miyake; Shoichi Watanuki; Yoichi Ishikawa; Yoshihito Funaki; Ren Iwata; Masatoshi Itoh; Kazuhiko Yanai
Journal:  Br J Clin Pharmacol       Date:  2008-04-11       Impact factor: 4.335

4.  Histamine H₁ receptor occupancy by the new-generation antidepressants fluvoxamine and mirtazapine: a positron emission tomography study in healthy volunteers.

Authors:  Hirotoshi Sato; Chihiro Ito; Manabu Tashiro; Kotaro Hiraoka; Katsuhiko Shibuya; Yoshihito Funaki; Ren Iwata; Hiroo Matsuoka; Kazuhiko Yanai
Journal:  Psychopharmacology (Berl)       Date:  2013-06-01       Impact factor: 4.530

5.  Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates.

Authors:  Magnus Schou; Katarina Varnäs; Stefan Lundquist; Ryuji Nakao; Nahid Amini; Akihiro Takano; Sjoerd J Finnema; Christer Halldin; Lars Farde
Journal:  Int J Neuropsychopharmacol       Date:  2015-03-26       Impact factor: 5.176

6.  Brain histamine H1 receptor occupancy after oral administration of desloratadine and loratadine.

Authors:  Tadaho Nakamura; Kotaro Hiraoka; Ryuichi Harada; Takuro Matsuzawa; Yoichi Ishikawa; Yoshihito Funaki; Takeo Yoshikawa; Manabu Tashiro; Kazuhiko Yanai; Nobuyuki Okamura
Journal:  Pharmacol Res Perspect       Date:  2019-07-12
  6 in total

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