Literature DB >> 15607479

Quantitative analysis of adenosine A1 receptors in human brain using positron emission tomography and [1-methyl-11C]8-dicyclopropylmethyl-1-methyl-3-propylxanthine.

Yuichi Kimura1, Kenji Ishii, Nobuyoshi Fukumitsu, Keiichi Oda, Toru Sasaki, Kazunori Kawamura, Kiichi Ishiwata.   

Abstract

Fully quantitative analysis of the adenosine A(1) receptor (A1R) in the brain with (11)C-MPDX and positron emission tomography is reported. The kinetics is described using a two-tissue three-compartment model, and estimated binding potentials correspond well with the estimates made by Logan plot. The image of the binding potential of the MPDX is physiologically reasonable. We conclude that MPDX is applicable to the visualization of the A1Rs in the brain with Logan plot.

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Year:  2004        PMID： 15607479     DOI： 10.1016/j.nucmedbio.2004.06.005

Source DB:  PubMed          Journal:  Nucl Med Biol        ISSN： 0969-8051            Impact factor:   2.408


  8 in total

Review 1.  Plasma radiometabolite correction in dynamic PET studies: Insights on the available modeling approaches.

Authors:  Matteo Tonietto; Gaia Rizzo; Mattia Veronese; Masahiro Fujita; Sami S Zoghbi; Paolo Zanotti-Fregonara; Alessandra Bertoldo
Journal:  J Cereb Blood Flow Metab       Date:  2015-10-14       Impact factor: 6.200

Review 2.  Image-derived input function for brain PET studies: many challenges and few opportunities.

Authors:  Paolo Zanotti-Fregonara; Kewei Chen; Jeih-San Liow; Masahiro Fujita; Robert B Innis
Journal:  J Cereb Blood Flow Metab       Date:  2011-08-03       Impact factor: 6.200

3.  Quantification of adenosine A2A receptors in the human brain using [11C]TMSX and positron emission tomography.

Authors:  Mika Naganawa; Yuichi Kimura; Masahiro Mishina; Yoshitsugu Manabe; Kunihiro Chihara; Keiichi Oda; Kenji Ishii; Kiichi Ishiwata
Journal:  Eur J Nucl Med Mol Imaging       Date:  2006-12-15       Impact factor: 9.236

Review 4.  PET imaging in multiple sclerosis.

Authors:  Daniele de Paula Faria; Sjef Copray; Carlos Buchpiguel; Rudi Dierckx; Erik de Vries
Journal:  J Neuroimmune Pharmacol       Date:  2014-05-09       Impact factor: 4.147

5.  Preclinical Evaluation of the First Adenosine A1 Receptor Partial Agonist Radioligand for Positron Emission Tomography Imaging.

Authors:  Min Guo; Zhan-Guo Gao; Ryan Tyler; Tyler Stodden; Yang Li; Joseph Ramsey; Wen-Jing Zhao; Gene-Jack Wang; Corinde E Wiers; Joanna S Fowler; Kenner C Rice; Kenneth A Jacobson; Sung Won Kim; Nora D Volkow
Journal:  J Med Chem       Date:  2018-11-13       Impact factor: 7.446

6.  Image-derived input function for human brain using high resolution PET imaging with [C](R)-rolipram and [C]PBR28.

Authors:  Paolo Zanotti-Fregonara; Jeih-San Liow; Masahiro Fujita; Elodie Dusch; Sami S Zoghbi; Elise Luong; Ronald Boellaard; Victor W Pike; Claude Comtat; Robert B Innis
Journal:  PLoS One       Date:  2011-02-25       Impact factor: 3.240

7.  Age-Related Decrease in Male Extra-Striatal Adenosine A1 Receptors Measured Using11C-MPDX PET.

Authors:  Masahiro Mishina; Yuichi Kimura; Muneyuki Sakata; Kenji Ishii; Keiichi Oda; Jun Toyohara; Kazumi Kimura; Kiichi Ishiwata
Journal:  Front Pharmacol       Date:  2017-12-18       Impact factor: 5.810

Review 8.  Molecular imaging of multiple sclerosis: from the clinical demand to novel radiotracers.

Authors:  Matteo Bauckneht; Selene Capitanio; Stefano Raffa; Luca Roccatagliata; Matteo Pardini; Caterina Lapucci; Cecilia Marini; Gianmario Sambuceti; Matilde Inglese; Paolo Gallo; Diego Cecchin; Flavio Nobili; Silvia Morbelli
Journal:  EJNMMI Radiopharm Chem       Date:  2019-04-08
  8 in total

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