| Literature DB >> 15607204 |
Jon Infante1, Javier Llorca, José Berciano, Onofre Combarros.
Abstract
In a case-control study using a clinically well-defined group of 41 multiple system atrophy (MSA) patients and 93 control subjects, the interleukin (IL)-8 (-251) TT genotype was associated with an approximately fourfold increased risk for MSA and, furthermore, this risk increased elevenfold with the simultaneous presence of the intercellular adhesion molecule-1 (ICAM-1: E469K) KK genotype, suggesting a gene-gene interaction. These data support a role for inflammation-related genes in risk for MSA.Entities:
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Year: 2005 PMID: 15607204 DOI: 10.1016/j.jns.2004.09.023
Source DB: PubMed Journal: J Neurol Sci ISSN: 0022-510X Impact factor: 3.181