BACKGROUND: Merkel cell carcinoma (MCC) is a dermal small blue-cell tumor that occurs in the elderly on the sun damaged head and neck. Epidermal involvement is unusual and MCC limited to the epidermis is very rare. CASE REPORT: A slightly tender pink hyperkeratotic papule was noted on the dorsal right hand of a 76-year-old man with a history of multiple skin cancers. An intraepidermal proliferation of small blue cells distributed in nests and single units at all levels of the epidermis was found within a solar keratosis and adjacent to an area of squamous cell carcinoma in situ. Cytokeratin 20 and neuron specific enolase highlighted these cells and failed to reveal dermal involvement. There was no residue on re-excision. CONCLUSION: We report the third case of MCC in situ. These lesions have only been reported in association with squamous neoplasms on the extremities.
BACKGROUND:Merkel cell carcinoma (MCC) is a dermal small blue-cell tumor that occurs in the elderly on the sun damaged head and neck. Epidermal involvement is unusual and MCC limited to the epidermis is very rare. CASE REPORT: A slightly tender pink hyperkeratotic papule was noted on the dorsal right hand of a 76-year-old man with a history of multiple skin cancers. An intraepidermal proliferation of small blue cells distributed in nests and single units at all levels of the epidermis was found within a solar keratosis and adjacent to an area of squamous cell carcinoma in situ. Cytokeratin 20 and neuron specific enolase highlighted these cells and failed to reveal dermal involvement. There was no residue on re-excision. CONCLUSION: We report the third case of MCC in situ. These lesions have only been reported in association with squamous neoplasms on the extremities.
Authors: Melissa P Pulitzer; A Rose Brannon; Michael F Berger; Peter Louis; Sasinya N Scott; Achim A Jungbluth; Daniel G Coit; Isaac Brownell; Klaus J Busam Journal: Mod Pathol Date: 2015-05-29 Impact factor: 7.842
Authors: Jeannine Bachmann; Jorg Kleeff; Frank Bergmann; Shailesh V Shrikhande; Wolfgang Hartschuh; Markus W Büchler; Helmut Friess Journal: World J Surg Oncol Date: 2005-09-01 Impact factor: 2.754
Authors: Alexis Harold; Yutaka Amako; Junichi Hachisuka; Yulong Bai; Meng Yen Li; Linda Kubat; Jan Gravemeyer; Jonathan Franks; Julia R Gibbs; Hyun Jung Park; Elena Ezhkova; Jürgen C Becker; Masahiro Shuda Journal: Proc Natl Acad Sci U S A Date: 2019-09-16 Impact factor: 11.205