| Literature DB >> 15606639 |
J Y Choi1, Y Soo Park, C H Cho, Y Seon Park, S Y Shin, Y G Song, D Yong, K Lee, J M Kim.
Abstract
The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-beta-lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 x MIC and 1 x MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35 degrees C.Entities:
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Year: 2004 PMID: 15606639 DOI: 10.1111/j.1469-0691.2004.00987.x
Source DB: PubMed Journal: Clin Microbiol Infect ISSN: 1198-743X Impact factor: 8.067