| Literature DB >> 15606097 |
Jan Doubský1, Ludvík Streinz, David Saman, Jirí Zedník, Bohumír Koutek.
Abstract
[reaction: see text] A simple and efficient two-step approach to spiroketals is described. Key steps include the preparation of functionalized hydroxyl alpha-alkynones by ring-opening reactions of lactones with lithium alkynyltrifluoroborates followed by a palladium-catalyzed hydrogenation/spirocyclization of the prespiroketal intermediate.Entities:
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Year: 2004 PMID： 15606097 DOI： 10.1021/ol047987k
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005