J A McNab1, A C Yung, P Kozlowski. 1. The Prostate Centre at VGH, 2660 Oak Street, Vancouver, BC, Canada, V6H 3Z6.
Abstract
OBJECTIVES: To investigate changes in tumour tissue oxygenation throughout the tumour growth-regression-relapse cycle in an androgen-dependent animal tumour model. MATERIALS AND METHODS: 19F T1 relaxometry of Perfluoro-15-Crown-5-Ether was used to measure in vivo partial oxygen pressure (pO2) of Shionogi tumours on a 2.35-T MR scanner. Perfluoro-15-Crown-5-Ether was administered as an emulsion injected intravenously or as a neat compound injected directly into the tumour. Non-localized, tumour 19F T1 measurements, made at multiple time points throughout the tumour cycle, were translated into pO2 levels. RESULTS: No correlation between tumour size and pO2 values was found. Values of pO2 for growing tumours (50 +/- 30 torr) were significantly lower than for regressing and relapsing tumours after 9 days post-castration (70 +/- 10 torr, p<0.05). Maximum pO2 values (90 +/- 30 torr) were reached between fifth and eighth day post-castration, when tumour pO2 was significantly higher than both pre-castration (p<0.001) and after 9 days post-castration (p<0.05). CONCLUSION: We demonstrate that longitudinal pO2 measurements in vivo are feasible. Values of pO2 for growing androgen-dependent tumours were significantly lower than for regressing and relapsing androgen-independent tumours. These results have potential clinical importance in optimizing the timing of chemotherapy and/or radiotherapy of hormone dependent tumours.
OBJECTIVES: To investigate changes in tumour tissue oxygenation throughout the tumour growth-regression-relapse cycle in an androgen-dependent animal tumour model. MATERIALS AND METHODS: 19F T1 relaxometry of Perfluoro-15-Crown-5-Ether was used to measure in vivo partial oxygen pressure (pO2) of Shionogi tumours on a 2.35-T MR scanner. Perfluoro-15-Crown-5-Ether was administered as an emulsion injected intravenously or as a neat compound injected directly into the tumour. Non-localized, tumour 19F T1 measurements, made at multiple time points throughout the tumour cycle, were translated into pO2 levels. RESULTS: No correlation between tumour size and pO2 values was found. Values of pO2 for growing tumours (50 +/- 30 torr) were significantly lower than for regressing and relapsing tumours after 9 days post-castration (70 +/- 10 torr, p<0.05). Maximum pO2 values (90 +/- 30 torr) were reached between fifth and eighth day post-castration, when tumourpO2 was significantly higher than both pre-castration (p<0.001) and after 9 days post-castration (p<0.05). CONCLUSION: We demonstrate that longitudinal pO2 measurements in vivo are feasible. Values of pO2 for growing androgen-dependent tumours were significantly lower than for regressing and relapsing androgen-independent tumours. These results have potential clinical importance in optimizing the timing of chemotherapy and/or radiotherapy of hormone dependent tumours.
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