Literature DB >> 15604411

bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.

Heather A Arnett1, Stephen P J Fancy, John A Alberta, Chao Zhao, Sheila R Plant, Sovann Kaing, Cedric S Raine, David H Rowitch, Robin J M Franklin, Charles D Stiles.   

Abstract

Olig1 and Olig2 are closely related basic helix-loop-helix (bHLH) transcription factors that are expressed in myelinating oligodendrocytes and their progenitor cells in the developing central nervous system (CNS). Olig2 is necessary for the specification of oligodendrocytes, but the biological functions of Olig1 during oligodendrocyte lineage development are poorly understood. We show here that Olig1 function in mice is required not to develop the brain but to repair it. Specifically, we demonstrate a genetic requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis.

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Year:  2004        PMID： 15604411     DOI： 10.1126/science.1103709

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  183 in total

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