| Literature DB >> 1560435 |
M H Cynamon1, S P Klemens, T S Chou, R H Gimi, J T Welch.
Abstract
A series of pyrazinoic acid esters has been prepared and evaluated for in vitro antimycobacterial activity. Several of the pyrazinoate esters have substantially better activity than the first-line antituberculous agent pyrazinamide against susceptible isolates of Mycobacterium turberculosis as well as activity against pyrazinamide-resistant isolates. The minimal inhibitory concentrations (MICs) were lower for each organism and at each pH than the MICs for pyrazinamide. The esters have activity against Mycobacterium bovis and Mycobacterium kansasii, two species resistant to pyrazinamide, but not against Mycobacterium avium complex.Entities:
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Year: 1992 PMID： 1560435 DOI： 10.1021/jm00085a007
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446