Yun-sheng Huang1, Wei Xie, Bao-tian Chen. 1. Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. hnhys2002@yahoo.com.cn
Abstract
OBJECTIVE: To study the effect of saikosaponins on the electroencephalogram (EEG) of epileptic rats to evaluate its therapeutic effect against epilepsies. METHODS: Sixty 8-week-old healthy SD rats were randomized into normal control group (A), epileptic model group (B), lamotrigine group (C), and 3 saikosaponin groups of small, moderate and high doses (D, E, and F groups, respectively), with 10 rats in each group. Penicillin was used to induce epilepsy in the latter 5 groups, and the EEG and onset of epileptic seizures were observed in each group. RESULTS: In group B, the EEG contained obvious epileptic discharges, which were not found in that in group A. After treatment with saikosaponins and lamotrignie, the EEG of group C and F became normal, whereas the EEG in group D still contained epileptic discharges at a low level, and that in group E was basically normal. The EEGs of group C, D, E, and F were significantly different from that in group B (P<0.001). CONCLUSION: Saikosaponins can obviously alleviate the severity of epileptic seizure in epileptic rats.
OBJECTIVE: To study the effect of saikosaponins on the electroencephalogram (EEG) of epilepticrats to evaluate its therapeutic effect against epilepsies. METHODS: Sixty 8-week-old healthy SD rats were randomized into normal control group (A), epileptic model group (B), lamotrigine group (C), and 3 saikosaponin groups of small, moderate and high doses (D, E, and F groups, respectively), with 10 rats in each group. Penicillin was used to induce epilepsy in the latter 5 groups, and the EEG and onset of epileptic seizures were observed in each group. RESULTS: In group B, the EEG contained obvious epileptic discharges, which were not found in that in group A. After treatment with saikosaponins and lamotrignie, the EEG of group C and F became normal, whereas the EEG in group D still contained epileptic discharges at a low level, and that in group E was basically normal. The EEGs of group C, D, E, and F were significantly different from that in group B (P<0.001). CONCLUSION:Saikosaponins can obviously alleviate the severity of epilepticseizure in epilepticrats.
Authors: Wei Xie; Yun Hong Yu; Yong Ping Du; Yun Yan Zhao; Chang Zheng Li; Lin Yu; Jian Hong Duan; Jun Ling Xing Journal: Evid Based Complement Alternat Med Date: 2013-02-21 Impact factor: 2.629