| Literature DB >> 15603944 |
Vanessa A de Souza1, Rosangela da Silva, Ana C Pereira, Vanessa de A Royo, Juliana Saraiva, Marisa Montanheiro, Gustavo H B de Souza, Ademar A da Silva Filho, Marcella D Grando, Paulo M Donate, Jairo K Bastos, Sérgio Albuquerque, Márcio L A e Silva.
Abstract
Five (-)-cubebin derivative compounds, (-)-O-acetyl cubebin (3), (-)-O-benzyl cubebin (4), (-)-O-(N,N-dimethylaminoethyl)-cubebin (5), (-)-hinokinin (6) and (-)-6,6'-dinitrohinokinin (7), previously synthesised by our research group, were evaluated on in vitro assay against free amastigote forms of Trypanosoma cruzi, the asogic agent of Chagas' disease. It was observed that 6 was the most active compound (IC(50)=0.7 microM), and that 4 and 5 displayed moderate activity against the parasite, giving IC(50) values of 5.7 and 4.7 microM, respectively. In contrast, it was observed that compound 3 was inactive and that 7 displayed low activity with IC(50) values of congruent with 1.5 x 10(4) and 95.3 microM, respectively.Entities:
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Year: 2005 PMID： 15603944 DOI： 10.1016/j.bmcl.2004.10.079
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823