Literature DB >> 15603260

Engineering protein A affinity chromatography.

Alois Jungbauer1, Rainer Hahn.   

Abstract

Staphylococcal protein A can selectively interact with immunoglobulins. This protein is widely used as a ligand for affinity chromatography to purify therapeutic antibodies on an industrial scale. This type of affinity chromatography constitutes a generic step in processing antibodies. Questions of scale-up, design of chromatographic conditions, clearance of adventitious agents and operational modes, such as continuous operation or purification of antibodies in expanded-bed mode, will be addressed in this review.

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Year:  2004        PMID： 15603260

Source DB:  PubMed          Journal:  Curr Opin Drug Discov Devel        ISSN： 1367-6733


  9 in total

1.  Immunoabsorbent nanoparticles based on a tobamovirus displaying protein A.

Authors:  Stefan Werner; Sylvestre Marillonnet; Gerd Hause; Victor Klimyuk; Yuri Gleba
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-07       Impact factor: 11.205

2.  Development of sulfhydryl-reactive silica for protein immobilization in high-performance affinity chromatography.

Authors:  Rangan Mallik; Chunling Wa; David S Hage
Journal:  Anal Chem       Date:  2007-02-15       Impact factor: 6.986

3.  Binding site on human immunoglobulin G for the affinity ligand HWRGWV.

Authors:  Haiou Yang; Patrick V Gurgel; D Keith Williams; Benjamin G Bobay; John Cavanagh; David C Muddiman; Ruben G Carbonell
Journal:  J Mol Recognit       Date:  2010 May-Jun       Impact factor: 2.137

4.  Highly efficient antibody purification with controlled orientation of protein A on magnetic nanoparticles.

Authors:  Sunghyun Kim; Daekyung Sung; Jeong Ho Chang
Journal:  Medchemcomm       Date:  2017-11-02       Impact factor: 3.597

5.  New platform for simple and rapid protein-based affinity reactions.

Authors:  Kei Kubota; Takuya Kubo; Tetsuya Tanigawa; Toyohiro Naito; Koji Otsuka
Journal:  Sci Rep       Date:  2017-03-14       Impact factor: 4.379

6.  Progress in affinity ligand-functionalized bacterial magnetosome nanoparticles for bio-immunomagnetic separation of HBsAg protein.

Authors:  Leila Hatami Giklou Jajan; Seyed Nezamedin Hosseini; Mohsen Abolhassani; Masoud Ghorbani
Journal:  PLoS One       Date:  2022-07-25       Impact factor: 3.752

7.  Quality by design approach for viral clearance by protein a chromatography.

Authors:  Min Zhang; George R Miesegaes; Michael Lee; Daniel Coleman; Bin Yang; Melody Trexler-Schmidt; Lenore Norling; Philip Lester; Kurt A Brorson; Qi Chen
Journal:  Biotechnol Bioeng       Date:  2013-08-16       Impact factor: 4.530

8.  High-level fed-batch fermentative expression of an engineered Staphylococcal protein A based ligand in E. coli: purification and characterization.

Authors:  Martin Kangwa; Vikas Yelemane; Ayse Nur Polat; Kanaka Durga Devi Gorrepati; Mariano Grasselli; Marcelo Fernández-Lahore
Journal:  AMB Express       Date:  2015-11-10       Impact factor: 3.298

9.  Antibody adsorption in protein-A affinity chromatography - in situ measurement of nanoscale structure by small-angle X-ray scattering.

Authors:  Jacek Plewka; Gonçalo L Silva; Rupert Tscheließnig; Harald Rennhofer; Cristina Dias-Cabral; Alois Jungbauer; Helga C Lichtenegger
Journal:  J Sep Sci       Date:  2018-10-16       Impact factor: 3.645
  9 in total

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