Literature DB >> 15602689

The role of the sympathetic nervous system and uncoupling proteins in the thermogenesis induced by 3,4-methylenedioxymethamphetamine.

Edward M Mills1, Daniel E Rusyniak, Jon E Sprague.   

Abstract

Body temperature regulation involves a homeostatic balance between heat production and dissipation. Sympathetic agents such as 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) can disrupt this balance and as a result produce an often life-threatening hyperthermia. The hyperthermia induced by MDMA appears to result from the activation of the sympathetic nervous system (SNS) and the hypothalamic-pituitary-thyroid/adrenal axis. Norepinephrine release mediated by MDMA creates a double-edged sword of heat generation through activation of uncoupling protein (UCP3) along with alpha1- and beta3-adrenoreceptors and loss of heat dissipation through SNS-mediated vasoconstriction. This review examines cellular mechanisms involved in MDMA-induced thermogenesis from UCP activation to vasoconstriction and how these mechanisms are related to other thermogenic conditions and potential treatment modalities.

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Year:  2004        PMID： 15602689     DOI： 10.1007/s00109-004-0591-7

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


  149 in total

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Authors:  A Lanni; M Moreno; A Lombardi; F Goglia
Journal:  FEBS Lett       Date:  2003-05-22       Impact factor: 4.124

2.  Pharmacodynamic effects of serotonin (5-HT) receptor ligands in pigs: stimulation of 5-HT2 receptors induces malignant hyperthermia.

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Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-06       Impact factor: 3.000

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Journal:  Physiol Rev       Date:  1969-04       Impact factor: 37.312

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Journal:  FEBS Lett       Date:  1999-02-12       Impact factor: 4.124

5.  Mitochondrial uncoupling proteins and phylogenesis--UCP4 as the ancestral uncoupling protein.

Authors:  P Hanák; P Jezek
Journal:  FEBS Lett       Date:  2001-04-27       Impact factor: 4.124

6.  Hypothalamic-pituitary-thyroid axis and sympathetic nervous system involvement in hyperthermia induced by 3,4-methylenedioxymethamphetamine (Ecstasy).

Authors:  Jon E Sprague; Matthew L Banks; Valerie J Cook; Edward M Mills
Journal:  J Pharmacol Exp Ther       Date:  2003-04       Impact factor: 4.030

Review 7.  Pentachlorophenol poisoning.

Authors:  Alex T Proudfoot
Journal:  Toxicol Rev       Date:  2003

8.  Stereochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain.

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Journal:  Biochem Pharmacol       Date:  1987-07-15       Impact factor: 5.858

9.  Rhabdomyolysis and shock after intravenous amphetamine administration.

Authors:  W C Kendrick; A R Hull; J P Knochel
Journal:  Ann Intern Med       Date:  1977-04       Impact factor: 25.391

Review 10.  The health effects of ecstasy: a literature review.

Authors:  Linda R Gowing; Susan M Henry-Edwards; Rodney J Irvine; Robert L Ali
Journal:  Drug Alcohol Rev       Date:  2002-03
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  27 in total

1.  Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans.

Authors:  Cm Hysek; Y Schmid; A Rickli; L D Simmler; M Donzelli; E Grouzmann; M E Liechti
Journal:  Br J Pharmacol       Date:  2012-08       Impact factor: 8.739

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Review 3.  A developmental comparison of the neurobehavioral effects of ecstasy (MDMA).

Authors:  Brian J Piper
Journal:  Neurotoxicol Teratol       Date:  2006-10-20       Impact factor: 3.763

Review 4.  Synthetic cathinones ("bath salts").

Authors:  Matthew L Banks; Travis J Worst; Daniel E Rusyniak; Jon E Sprague
Journal:  J Emerg Med       Date:  2014-02-22       Impact factor: 1.484

Review 5.  Prenatal antidepressant exposure: clinical and preclinical findings.

Authors:  Chase H Bourke; Zachary N Stowe; Michael J Owens
Journal:  Pharmacol Rev       Date:  2014-02-24       Impact factor: 25.468

6.  Drugs and bugs: turning on the heat through UCP1 and UCP3.

Authors:  Mary-Ellen Harper
Journal:  J Physiol       Date:  2016-12-15       Impact factor: 5.182

7.  Studies on the effect of MDMA ('ecstasy') on the body temperature of rats housed at different ambient room temperatures.

Authors:  A Richard Green; Esther O'Shea; Kathryn S Saadat; J Martin Elliott; M Isabel Colado
Journal:  Br J Pharmacol       Date:  2005-09       Impact factor: 8.739

Review 8.  The role of monoamines in the changes in body temperature induced by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and its derivatives.

Authors:  J R Docherty; A R Green
Journal:  Br J Pharmacol       Date:  2010-07       Impact factor: 8.739

9.  Impact of ambient temperature on hyperthermia induced by (+/-)3,4-methylenedioxymethamphetamine in rhesus macaques.

Authors:  Stefani N Von Huben; Christopher C Lay; Rebecca D Crean; Sophia A Davis; Simon N Katner; Michael A Taffe
Journal:  Neuropsychopharmacology       Date:  2006-04-12       Impact factor: 7.853

10.  Differential behavioral syndrome evoked in the rats after multiple doses of SSRI fluoxetine with selective MAO inhibitors rasagiline or selegiline.

Authors:  Z Speiser; T Fine; L Litinetsky; S Eliash; E Blaugrund; S Cohen
Journal:  J Neural Transm (Vienna)       Date:  2007-09-07       Impact factor: 3.575
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