Literature DB >> 15600307

Use of a retroinverso p53 peptide as an inhibitor of MDM2.

Kaori Sakurai1, Hak Suk Chung, Daniel Kahne.   

Abstract

An N-terminal helical region of the tumor suppressor p53 binds in a hydrophobic cleft of the oncoprotein MDM2. A retroinverso isomer of the natural N-terminal helical peptide was found to interact with MDM2 using the same hydrophobic residues, Phe, Trp, and Leu. We propose that the retroinverso d-peptide adopts a right-handed helical conformation to achieve functional mimicry of the p53 peptide.

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Year:  2004        PMID： 15600307     DOI： 10.1021/ja044883w

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  16 in total

1.  Limitations of peptide retro-inverso isomerization in molecular mimicry.

Authors:  Chong Li; Marzena Pazgier; Jing Li; Changqing Li; Min Liu; Guozhang Zou; Zhenyu Li; Jiandong Chen; Sergey G Tarasov; Wei-Yue Lu; Wuyuan Lu
Journal:  J Biol Chem       Date:  2010-04-09       Impact factor: 5.157

2.  Identification of a Structural Determinant for Selective Targeting of HDMX.

Authors:  Yael Ben-Nun; Hyuk-Soo Seo; Edward P Harvey; Zachary J Hauseman; Thomas E Wales; Catherine E Newman; Ann M Cathcart; John R Engen; Sirano Dhe-Paganon; Loren D Walensky
Journal:  Structure       Date:  2020-04-30       Impact factor: 5.006

3.  Solution structure of a beta-peptide ligand for hDM2.

Authors:  Joshua A Kritzer; Michael E Hodsdon; Alanna Schepartz
Journal:  J Am Chem Soc       Date:  2005-03-30       Impact factor: 15.419

4.  Integrating the intrinsic conformational preferences of noncoded α-amino acids modified at the peptide bond into the noncoded amino acids database.

Authors:  Guillem Revilla-López; Francisco Rodríguez-Ropero; David Curcó; Juan Torras; M Isabel Calaza; David Zanuy; Ana I Jiménez; Carlos Cativiela; Ruth Nussinov; Carlos Alemán
Journal:  Proteins       Date:  2011-04-12

5.  Beta-peptides with improved affinity for hDM2 and hDMX.

Authors:  Elizabeth A Harker; Douglas S Daniels; Danielle A Guarracino; Alanna Schepartz
Journal:  Bioorg Med Chem       Date:  2009-01-23       Impact factor: 3.641

6.  Design and Synthesis of Functionalized Trisaccharides as p53-Peptide Mimics.

Authors:  Kaori Sakurai; Daniel Kahne
Journal:  Tetrahedron Lett       Date:  2010-07-21       Impact factor: 2.415

7.  (D)-Amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Ialpha.

Authors:  Christian K Nickl; Shiv Kumar Raidas; Hong Zhao; Matthias Sausbier; Peter Ruth; Werner Tegge; Joseph E Brayden; Wolfgang R Dostmann
Journal:  Biochim Biophys Acta       Date:  2009-12-16

8.  Novel peptide isomer strategy for stable inhibition of catecholamine release: application to hypertension.

Authors:  Nilima Biswas; Jiaur Gayen; Manjula Mahata; Ying Su; Sushil K Mahata; Daniel T O'Connor
Journal:  Hypertension       Date:  2012-11-05       Impact factor: 10.190

9.  An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production.

Authors:  Yuan Tian; Bhramdeo Bassit; Deming Chau; Yue-Ming Li
Journal:  Nat Struct Mol Biol       Date:  2010-01-10       Impact factor: 15.369

10.  Functional consequences of retro-inverso isomerization of a miniature protein inhibitor of the p53-MDM2 interaction.

Authors:  Chong Li; Changyou Zhan; Le Zhao; Xishan Chen; Wei-Yue Lu; Wuyuan Lu
Journal:  Bioorg Med Chem       Date:  2013-04-22       Impact factor: 3.641
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