Literature DB >> 15600248

Maribavir (ViroPharma).

Henry Lu1, Sun Thomas.   

Abstract

ViroPharma, under license from GlaxoSmithKline, is developing maribavir, a DNA synthesis inhibitor for the potential prevention and treatment of human cytomegalovirus infections related to transplants (including solid organ and hematopoietic stem cells), congenital transmission, and in patients with HIV infection. In July 2004, a phase II trial was initiated.

Entities:  

Mesh:

Substances:

Year:  2004        PMID: 15600248

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN: 1472-4472


  5 in total

1.  Enzymatic activities of human cytomegalovirus maturational protease assemblin and its precursor (pPR, pUL80a) are comparable: [corrected] maximal activity of pPR requires self-interaction through its scaffolding domain.

Authors:  Edward J Brignole; Wade Gibson
Journal:  J Virol       Date:  2007-02-07       Impact factor: 5.103

2.  Maribavir pharmacokinetics and the effects of multiple-dose maribavir on cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-acetyltransferase-2, and xanthine oxidase activities in healthy adults.

Authors:  Joseph D Ma; Anne N Nafziger; Stephen A Villano; Andrea Gaedigk; Joseph S Bertino
Journal:  Antimicrob Agents Chemother       Date:  2006-04       Impact factor: 5.191

3.  Effect of ketoconazole on the pharmacokinetics of maribavir in healthy adults.

Authors:  D Ronald Goldwater; Carolyn Dougherty; Mary Schumacher; Stephen A Villano
Journal:  Antimicrob Agents Chemother       Date:  2008-03-03       Impact factor: 5.191

4.  The effects of maribavir on the autophosphorylation of ganciclovir resistant mutants of the cytomegalovirus UL97 protein.

Authors:  Claire D Shannon-Lowe; Vincent C Emery
Journal:  Herpesviridae       Date:  2010-12-07

5.  Viral and cell cycle-regulated kinases in cytomegalovirus-induced pseudomitosis and replication.

Authors:  Laura Hertel; Sunwen Chou; Edward S Mocarski
Journal:  PLoS Pathog       Date:  2007-01       Impact factor: 6.823

  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.