Literature DB >> 15599640

Detecting non-multiplicative genotype relative risks from transmissions of parental alleles to affected children.

Karen L Ayres1, Robert N Curnow2.   

Abstract

The differential transmission of alleles from parents to affected children indicates that the locus under investigation is either directly involved in the occurrence of the disease or that there are allelic associations with other loci that are directly involved. Conditional logistic regression applied to a diallelic locus leads to a test with two degrees of freedom. The power of a single degree of freedom test to detect non-multiplicative allelic effects is discussed here.

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Year:  2004        PMID: 15599640     DOI: 10.1007/s10038-004-0217-5

Source DB:  PubMed          Journal:  J Hum Genet        ISSN: 1434-5161            Impact factor:   3.172


  6 in total

1.  Likelihoods and TDT for the case-parents design.

Authors:  D J Schaid
Journal:  Genet Epidemiol       Date:  1999       Impact factor: 2.135

2.  On estimating HLA/disease association with application to a study of aplastic anemia.

Authors:  S G Self; G Longton; K J Kopecky; K Y Liang
Journal:  Biometrics       Date:  1991-03       Impact factor: 2.571

3.  General score tests for associations of genetic markers with disease using cases and their parents.

Authors:  D J Schaid
Journal:  Genet Epidemiol       Date:  1996       Impact factor: 2.135

4.  Genotype relative risks: methods for design and analysis of candidate-gene association studies.

Authors:  D J Schaid; S S Sommer
Journal:  Am J Hum Genet       Date:  1993-11       Impact factor: 11.025

5.  Comparison of statistics for candidate-gene association studies using cases and parents.

Authors:  D J Schaid; S S Sommer
Journal:  Am J Hum Genet       Date:  1994-08       Impact factor: 11.025

6.  Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

Authors:  R S Spielman; R E McGinnis; W J Ewens
Journal:  Am J Hum Genet       Date:  1993-03       Impact factor: 11.025

  6 in total

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