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Literature DB >> 15599393

Acid sensing in renal epithelial cells.

Abstract

The kidney adjusts net acid excretion to match production with exquisite precision, despite little or no change in the plasma bicarbonate concentration. The acid-sensing pathway that signals the kidney to increase acid secretion involves activation of the proto-oncogene c-Src. A new study in this issue shows that proline-rich tyrosine kinase 2 (Pyk2) is responsible for acid-induced activation of c-Src and is essential for acid sensing in renal epithelial cells. The findings implicate a broader role for Pyk2 in acid-base homeostasis in bone and other tissues beyond the kidney.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2004 PMID： 15599393 PMCID： PMC535075 DOI： 10.1172/JCI23864

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

35 in total

Review 1. Acute regulation of proximal tubule apical membrane Na/H exchanger NHE-3: role of phosphorylation, protein trafficking, and regulatory factors.

Authors: O W Moe
Journal: J Am Soc Nephrol Date: 1999-11 Impact factor: 10.121

Review 2. Pathophysiology of hypocitraturic nephrolithiasis.

Authors: L Lee Hamm; Kathleen S Hering-Smith
Journal: Endocrinol Metab Clin North Am Date: 2002-12 Impact factor: 4.741

Review 3. RAFTK/Pyk2-mediated cellular signalling.

Authors: H Avraham; S Y Park; K Schinkmann; S Avraham
Journal: Cell Signal Date: 2000-03 Impact factor: 4.315

Review 4. Diet, evolution and aging--the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet.

Authors: L Frassetto; R C Morris; D E Sellmeyer; K Todd; A Sebastian
Journal: Eur J Nutr Date: 2001-10 Impact factor: 5.614

5. Preincubation in acid medium increases Na/H antiporter activity in cultured renal proximal tubule cells.

Authors: S Horie; O Moe; A Tejedor; R J Alpern
Journal: Proc Natl Acad Sci U S A Date: 1990-06 Impact factor: 11.205

Review 6. The hunting of the Src.

Authors: G S Martin
Journal: Nat Rev Mol Cell Biol Date: 2001-06 Impact factor: 94.444

Acid sensing in renal epithelial cells.

Review 1. Acute regulation of proximal tubule apical membrane Na/H exchanger NHE-3: role of phosphorylation, protein trafficking, and regulatory factors.

Review 2. Pathophysiology of hypocitraturic nephrolithiasis.

Review 3. RAFTK/Pyk2-mediated cellular signalling.

Review 4. Diet, evolution and aging--the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet.

5. Preincubation in acid medium increases Na/H antiporter activity in cultured renal proximal tubule cells.

Review 6. The hunting of the Src.

Review 7. The role of endothelin in proximal tubule proton secretion and the adaptation to a chronic metabolic acidosis.

8. Selective involvement of p130Cas/Crk/Pyk2/c-Src in endothelin-1-induced JNK activation.

Review 9. Regulation of endothelial cell function BY FAK and PYK2.

10. A central role for Pyk2-Src interaction in coupling diverse stimuli to increased epithelial NBC activity.

Review 1. Regulation of transport in the connecting tubule and cortical collecting duct.

Review 2. Physiological carbon dioxide, bicarbonate, and pH sensing.

Review 3. Transcriptional regulation of the pendrin gene.

4. Deletion of the pH sensor GPR4 decreases renal acid excretion.

Review 5. Clinical review: Renal tubular acidosis--a physicochemical approach.

Review 6. Sensing, physiological effects and molecular response to elevated CO2 levels in eukaryotes.