Literature DB >> 15598572

Synthesis and neuroprotective activity of analogues of glycyl-L-prolyl-L-glutamic acid (GPE) modified at the alpha-carboxylic acid.

Nicholas S Trotter1, Margaret A Brimble, Paul W R Harris, David J Callis, Frank Sieg.   

Abstract

The synthesis of nine GPE* analogues, wherein the alpha-carboxylic acid group of glutamic acid has been modified, is described by coupling readily accessible N-benzyloxycarbonyl-glycyl-L-proline 2 with various analogues of glutamic acid. Pharmacological evaluation of the novel compounds was undertaken to further understand the role of the glutamate residue on the observed neuroprotective properties of the endogenous tripeptide GPE.

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Year:  2005        PMID： 15598572     DOI： 10.1016/j.bmc.2004.10.005

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  3 in total

1.  Straightforward synthesis of various chiral pyrimidines bearing a stereogenic center adjacent to the C-2 position, including C-terminal peptide isosteres.

Authors:  Sami Sahtel; Chayma Ben Maamer; Rafâa Besbes; Emmanuel Vrancken; Jean-Marc Campagne
Journal:  Amino Acids       Date:  2022-10-13       Impact factor: 3.789

2.  A Sustainable Approach for Synthesizing (R)-4-Aminopentanoic Acid From Levulinic Acid Catalyzed by Structure-Guided Tailored Glutamate Dehydrogenase.

Authors:  Feng Zhou; Yan Xu; Xiaoqing Mu; Yao Nie
Journal:  Front Bioeng Biotechnol       Date:  2022-01-10

3.  Design, automated synthesis and immunological evaluation of NOD2-ligand-antigen conjugates.

Authors:  Marian M J H P Willems; Gijs G Zom; Nico Meeuwenoord; Ferry A Ossendorp; Herman S Overkleeft; Gijsbert A van der Marel; Jeroen D C Codée; Dmitri V Filippov
Journal:  Beilstein J Org Chem       Date:  2014-06-26       Impact factor: 2.883
  3 in total

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