BACKGROUND: The marked variability in age at onset of colorectal cancer (CRC) in patients with hereditary nonpolyposis colorectal cancer (HNPCC) makes management decisions difficult. Environmental factors governing the phenotypic variability of cancer-associated syndromes such as HNPCC have not been elucidated. METHODS: We determined whether tobacco use would alter CRC risk in carriers of HNPCC-associated mutations, using a retrospective cohort study of germline mutation (hMLH1 or hMSH2) carriers from the Hereditary Cancer Institute at Creighton University, one of the oldest and largest registries of HNPCC patients. The main outcome measure was age at CRC onset, estimated by means of Cox proportional hazards modeling. RESULTS: Tobacco use, hMLH1 mutation carriage (as opposed to hMSH2), and male sex were significantly associated with increased risk of CRC (hazard ratios, 1.43, 2.07, and 1.58, respectively). Alcohol use did not alter CRC risk. CONCLUSIONS: Smoking cessation should be an integral part of HNPCC management. This study underscores the gene x environment interactions in cancer development.
BACKGROUND: The marked variability in age at onset of colorectal cancer (CRC) in patients with hereditary nonpolyposis colorectal cancer (HNPCC) makes management decisions difficult. Environmental factors governing the phenotypic variability of cancer-associated syndromes such as HNPCC have not been elucidated. METHODS: We determined whether tobacco use would alter CRC risk in carriers of HNPCC-associated mutations, using a retrospective cohort study of germline mutation (hMLH1 or hMSH2) carriers from the Hereditary Cancer Institute at Creighton University, one of the oldest and largest registries of HNPCC patients. The main outcome measure was age at CRC onset, estimated by means of Cox proportional hazards modeling. RESULTS:Tobacco use, hMLH1 mutation carriage (as opposed to hMSH2), and male sex were significantly associated with increased risk of CRC (hazard ratios, 1.43, 2.07, and 1.58, respectively). Alcohol use did not alter CRC risk. CONCLUSIONS: Smoking cessation should be an integral part of HNPCC management. This study underscores the gene x environment interactions in cancer development.
Authors: M M Blokhuis; G E Pietersen; P A Goldberg; U Algar; L Van der Merwe; N Mbatani; A A Vorster; R S Ramesar Journal: Fam Cancer Date: 2010-09 Impact factor: 2.375
Authors: Adriana M Coletta; Susan K Peterson; Leticia A Gatus; Kate J Krause; Susan M Schembre; Susan C Gilchrist; Mala Pande; Eduardo Vilar; Y Nancy You; Miguel A Rodriguez-Bigas; Larkin L Strong; Patrick M Lynch; Karen H Lu; Karen Basen-Engquist Journal: Fam Cancer Date: 2019-06-24 Impact factor: 2.375
Authors: Fränzel J B van Duijnhoven; Akke Botma; Renate Winkels; Fokko M Nagengast; Hans F A Vasen; Ellen Kampman Journal: Fam Cancer Date: 2013-06 Impact factor: 2.375
Authors: Rhonda M Brand; David D Jones; Henry T Lynch; Randall E Brand; Patrice Watson; Ramesh Ashwathnayaran; Hemant K Roy Journal: World J Gastroenterol Date: 2006-07-28 Impact factor: 5.742
Authors: Henry T Lynch; Stephen Lanspa; Trudy Shaw; Murray Joseph Casey; Marc Rendell; Mark Stacey; Theresa Townley; Carrie Snyder; Megan Hitchins; Joan Bailey-Wilson Journal: Fam Cancer Date: 2018-07 Impact factor: 2.375
Authors: Joanne Soo-Min Kim; Peter C Coyte; Michelle Cotterchio; Louise A Keogh; Louisa B Flander; Clara Gaff; Audrey Laporte Journal: Cancer Epidemiol Biomarkers Prev Date: 2016-08-15 Impact factor: 4.254
Authors: Karen Curtin; Wade S Samowitz; Roger K Wolff; Jennifer Herrick; Bette J Caan; Martha L Slattery Journal: Int J Cancer Date: 2009-07-01 Impact factor: 7.396
Authors: Rowena Chau; Seyedeh Ghazaleh Dashti; Driss Ait Ouakrim; Daniel D Buchanan; Mark Clendenning; Christophe Rosty; Ingrid M Winship; Joanne P Young; Graham G Giles; Finlay A Macrae; Alex Boussioutas; Susan Parry; Jane C Figueiredo; A Joan Levine; Dennis J Ahnen; Graham Casey; Robert W Haile; Steven Gallinger; Loïc Le Marchand; Stephen N Thibodeau; Noralane M Lindor; Polly A Newcomb; John D Potter; John A Baron; John L Hopper; Mark A Jenkins; Aung Ko Win Journal: Int J Epidemiol Date: 2016-04-10 Impact factor: 7.196