OBJECTIVES: To evaluate the expression of cyclooxygenase-2 (COX-2) and its association with clinicopathologic parameters, and to investigate the relationships between COX-2 expression and inflammation and carcinogenesis in human renal cell carcinoma. COX-2 expression is associated with aggressive clinicopathologic parameters and an unfavorable prognosis in several human malignancies. METHODS: COX-2 expression was examined immunohistochemically in tumor tissues obtained from 71 patients who underwent radical nephrectomy for renal cell carcinoma. The correlation between COX-2 expression and clinicopathologic findings and patient survival was determined. RESULTS: Of 71 tumors, 63.4% were positive for COX-2 expression. Correlation was found between COX-2 expression and various clinicopathologic features, including tumor size, tumor stage, and tumor grade (P = 0.038, P = 0.004, and P = 0.004, respectively). We found no relationship between COX-2 expression and patient survival. However, the immunoreactivity of COX-2 in renal cell carcinoma and peritumoral areas with inflammation was greater than in areas without inflammation. A statistically significant correlation was found between COX-2 expression and the tubules associated with inflammation (P = 0.038). CONCLUSIONS: COX-2 expression in patients with renal cell carcinoma is associated with several clinicopathologic features. COX-2 expression seems to play a role in the inflammation-carcinoma sequence in renal cell carcinoma. Additional research is required to determine the link between carcinogenesis and inflammation in renal cell carcinoma.
OBJECTIVES: To evaluate the expression of cyclooxygenase-2 (COX-2) and its association with clinicopathologic parameters, and to investigate the relationships between COX-2 expression and inflammation and carcinogenesis in humanrenal cell carcinoma. COX-2 expression is associated with aggressive clinicopathologic parameters and an unfavorable prognosis in several humanmalignancies. METHODS:COX-2 expression was examined immunohistochemically in tumor tissues obtained from 71 patients who underwent radical nephrectomy for renal cell carcinoma. The correlation between COX-2 expression and clinicopathologic findings and patient survival was determined. RESULTS: Of 71 tumors, 63.4% were positive for COX-2 expression. Correlation was found between COX-2 expression and various clinicopathologic features, including tumor size, tumor stage, and tumor grade (P = 0.038, P = 0.004, and P = 0.004, respectively). We found no relationship between COX-2 expression and patient survival. However, the immunoreactivity of COX-2 in renal cell carcinoma and peritumoral areas with inflammation was greater than in areas without inflammation. A statistically significant correlation was found between COX-2 expression and the tubules associated with inflammation (P = 0.038). CONCLUSIONS:COX-2 expression in patients with renal cell carcinoma is associated with several clinicopathologic features. COX-2 expression seems to play a role in the inflammation-carcinoma sequence in renal cell carcinoma. Additional research is required to determine the link between carcinogenesis and inflammation in renal cell carcinoma.
Authors: Sarfraz Ali; Qiqin Yin-Goen; Timothy V Johnson; Wei Han; Nicole A Johnson; Wayne B Harris; Fray F Marshall; Andrew N Young; Viraj A Master; Adeboye O Osunkoya Journal: Tumour Biol Date: 2010-11-18
Authors: Albrecht Reichle; Jochen Grassinger; Klaus Bross; Jochen Wilke; Thomas Suedhoff; Bernhard Walter; Wolf-Ferdinand Wieland; Anna Berand; Reinhard Andreesen Journal: Biomark Insights Date: 2007-02-07
Authors: X Wang; L Zhang; A O'Neill; B Bahamon; D C Alsop; J W Mier; S N Goldberg; S Signoretti; M B Atkins; C G Wood; R S Bhatt Journal: Br J Cancer Date: 2013-01-15 Impact factor: 7.640
Authors: Ji Won Lee; Jeong Hwan Park; Ja Hee Suh; Kyung Han Nam; Ji-Young Choe; Hae Yoen Jung; Ji Yoen Chae; Kyung Chul Moon Journal: Korean J Pathol Date: 2012-06-22