| Literature DB >> 15596125 |
Tsuneyasu Kaisho1, Shizuo Akira.
Abstract
A group of type I transmembrane proteins, Toll-like receptors (TLRs) discriminate various microorganism-associated molecular structures that can function as immune adjuvants. Each TLR signaling has an overlapping but distinct function, which largely depends on intracellular adaptor molecules. Clarifying the functions and signaling of TLRs should provide us with critical information for manipulating the host defense mechanism.Mesh:
Substances:
Year: 2004 PMID: 15596125 DOI: 10.1016/j.micinf.2004.08.019
Source DB: PubMed Journal: Microbes Infect ISSN: 1286-4579 Impact factor: 2.700