| Literature DB >> 15596121 |
Katherine A Fitzgerald1, Daniel C Rowe, Douglas T Golenbock.
Abstract
Bacterial lipopolysaccharides are recognized in mammals by a receptor complex composed of CD14, Toll-like receptor (TLR)-4 and MD-2. Transduction of signaling is achieved following the recruitment of a combination of four Toll-interleukin-1 resistance (TIR)-domain-containing adapter molecules, which provide a structural platform enabling the recruitment and activation of downstream effectors essential for pathway-specific transcription factor activation and inflammatory gene expression.Entities:
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Year: 2004 PMID： 15596121 DOI： 10.1016/j.micinf.2004.08.015
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700