Literature DB >> 15595441

Continuous flow microreactors for drug discovery.

Paul Watts1.   

Abstract

This article reviews the use of microreactors in the field of organic and combinatorial synthesis with regard to drug discovery applications. Research conducted into microreactors that enable in situ purification is described, and it is proposed that compounds could potentially be screened within an integrated bioassay system. A description of how it would be possible to use this technology to prepare larger quantities of pharmaceutical intermediates is also given.

Mesh:

Substances:

Year:  2004        PMID: 15595441

Source DB:  PubMed          Journal:  Curr Opin Drug Discov Devel        ISSN: 1367-6733


  3 in total

1.  Automated Multistep Continuous Flow Synthesis of 2-(1H-Indol-3-yl)thiazole Derivatives.

Authors:  Nicholas Pagano; Marintha L Heil; Nicholas D P Cosford
Journal:  Synthesis (Stuttg)       Date:  2012       Impact factor: 3.157

2.  An Automated Process for a Sequential Heterocycle/Multicomponent Reaction: Multistep Continuous Flow Synthesis of 5-(Thiazol-2-yl)-3,4-Dihydropyrimidin-2(1H)-ones.

Authors:  Nicholas Pagano; Ananda Herath; Nicholas D P Cosford
Journal:  J Flow Chem       Date:  2011-08-25       Impact factor: 2.786

3.  Rapid catalyst screening by a continuous-flow microreactor interfaced with ultra-high-pressure liquid chromatography.

Authors:  Hui Fang; Qing Xiao; Fanghui Wu; Paul E Floreancig; Stephen G Weber
Journal:  J Org Chem       Date:  2010-08-20       Impact factor: 4.354

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.