BACKGROUND: Transforming growth factor beta1 (TGF-beta1) plays an important role in tissue fibrosis and has been found to participate in cardiovascular disease (CVD). This study aimed to evaluate the association of TGF-beta1 polymorphisms with chronic renal disease (CRD), and its progression to dialysis in a retrospective longitudinal study of an end-stage renal disease (ESRD) cohort. METHODS: The Arg/Pro (codon 25) and Leu/Pro (codon 10) polymorphisms were genotyped in 104 ESRD patients aged 64 +/- 14 yrs (mean +/- SD), 62 males, and in 104 matched controls. RESULTS: The genotype distribution of Leu10Pro and Arg25Pro polymorphisms was different between patients and controls: Leu/Leu, Leu/Pro, Pro/Pro: 0.35, 0.50, 0.15 vs. 0.30, 0.24, 0.46 (p=0.001) and Arg/Arg, Arg/Pro, Pro/Pro: 0.79, 0.21, 0 vs. 0.87, 0.10, 0.03 (p=0.019). Similarly, haplotypes constructed with the combination of both polymorphisms were different among groups. There were no differences in CRD progression rate among genotypes. Codon 10 Leu allele was associated with the presence of clinical CVD in the ESRD patients (Leu/Leu, Leu/Pro, Pro/Pro: with CVD 0.49, 0.49, 0.02 vs. without CVD 0.27, 0.51, 0.22 (p=0.01). Combined polymorphism haplotypes were also significantly different between ESRD patients with and without CVD. This association was independent from other risk factors. CONCLUSIONS: TGF-beta1 polymorphisms are associated with ESRD, particularly in patients with associated clinical CVD, and could be useful as genetic markers of CRD and higher cardiovascular risk.
BACKGROUND:Transforming growth factor beta1 (TGF-beta1) plays an important role in tissue fibrosis and has been found to participate in cardiovascular disease (CVD). This study aimed to evaluate the association of TGF-beta1 polymorphisms with chronic renal disease (CRD), and its progression to dialysis in a retrospective longitudinal study of an end-stage renal disease (ESRD) cohort. METHODS: The Arg/Pro (codon 25) and Leu/Pro (codon 10) polymorphisms were genotyped in 104 ESRDpatients aged 64 +/- 14 yrs (mean +/- SD), 62 males, and in 104 matched controls. RESULTS: The genotype distribution of Leu10Pro and Arg25Pro polymorphisms was different between patients and controls: Leu/Leu, Leu/Pro, Pro/Pro: 0.35, 0.50, 0.15 vs. 0.30, 0.24, 0.46 (p=0.001) and Arg/Arg, Arg/Pro, Pro/Pro: 0.79, 0.21, 0 vs. 0.87, 0.10, 0.03 (p=0.019). Similarly, haplotypes constructed with the combination of both polymorphisms were different among groups. There were no differences in CRD progression rate among genotypes. Codon 10 Leu allele was associated with the presence of clinical CVD in the ESRDpatients (Leu/Leu, Leu/Pro, Pro/Pro: with CVD 0.49, 0.49, 0.02 vs. without CVD 0.27, 0.51, 0.22 (p=0.01). Combined polymorphism haplotypes were also significantly different between ESRDpatients with and without CVD. This association was independent from other risk factors. CONCLUSIONS:TGF-beta1 polymorphisms are associated with ESRD, particularly in patients with associated clinical CVD, and could be useful as genetic markers of CRD and higher cardiovascular risk.
Authors: Caren Cristina Grabulosa; Marcelo Costa Batista; Miguel Cendoroglo; Beata Marie Redublo Quinto; Roberto Narciso; Julio Cesar Monte; Marcelino Durão; Luiz Vicente Rizzo; Oscar Fernando Pavão Santos; Maria Aparecida Dalboni Journal: Biomed Res Int Date: 2014-07-23 Impact factor: 3.411
Authors: Mai Tuyet Vuong; Sigrid Lundberg; Iva Gunnarsson; Lars Wramner; Maria Seddighzadeh; Mirjana Hahn-Zoric; Anders Fernström; Lars A Hanson; Lieu Thi Do; Stefan H Jacobson; Leonid Padyukov Journal: Nephrol Dial Transplant Date: 2009-03-03 Impact factor: 5.992
Authors: Katarzyna Nabrdalik; Janusz Gumprecht; Piotr Adamczyk; Sylwia Górczyńska-Kosiorz; Joanna Zywiec; Władysław Grzeszczak Journal: Arch Med Sci Date: 2013-04-09 Impact factor: 3.318
Authors: Pushplata Prasad; Arun K Tiwari; K M Prasanna Kumar; A C Ammini; Arvind Gupta; Rajeev Gupta; B K Thelma Journal: BMC Med Genet Date: 2007-04-12 Impact factor: 2.103