| Literature DB >> 15592462 |
Eva M Neuhaus1, Günter Gisselmann, Weiyi Zhang, Ruth Dooley, Klemens Störtkuhl, Hanns Hatt.
Abstract
Despite increasing knowledge about dimerization of G-protein-coupled receptors, nothing is known about dimerization in the largest subfamily, odorant receptors. Using a combination of biochemical and electrophysiological approaches, we demonstrate here that odorant receptors can dimerize. DOR83b, an odorant receptor that is ubiquitously expressed in olfactory neurons from Drosophila melanogaster and highly conserved among insect species, forms heterodimeric complexes with other odorant-receptor proteins, which strongly increases their functionality.Entities:
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Year: 2004 PMID： 15592462 DOI： 10.1038/nn1371
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884