OBJECTIVES: In the past essential thrombocythemia was considered a disease of the elderly. At present, the number of young people suffering from this disease is growing, with a slightly higher frequency in females. We investigated the effects of interferon alfa therapy in these patients. STUDY DESIGN: We describe 9 pregnancies in 4 women affected by essential thrombocythemia. RESULTS: Four pregnancies were carried out without interferon alfa therapy, and resulted in 2 intrauterine deaths, 1 spontaneous abortion, and 1 neonatal death. Interferon alfa was given during another 5 pregnancies; among them, 2 ended in preterm deliveries with normal infants, and 3 in full-term deliveries. The literature is reviewed. CONCLUSION: Our cases and published series suggest that fetal outcome is improved by therapy, and that interferon alfa may be the best therapeutic option.
OBJECTIVES: In the past essential thrombocythemia was considered a disease of the elderly. At present, the number of young people suffering from this disease is growing, with a slightly higher frequency in females. We investigated the effects of interferon alfa therapy in these patients. STUDY DESIGN: We describe 9 pregnancies in 4 women affected by essential thrombocythemia. RESULTS: Four pregnancies were carried out without interferon alfa therapy, and resulted in 2 intrauterine deaths, 1 spontaneous abortion, and 1 neonatal death. Interferon alfa was given during another 5 pregnancies; among them, 2 ended in preterm deliveries with normal infants, and 3 in full-term deliveries. The literature is reviewed. CONCLUSION: Our cases and published series suggest that fetal outcome is improved by therapy, and that interferon alfa may be the best therapeutic option.
Authors: Lukas Schrickel; Florian H Heidel; Parvis Sadjadian; Tatjana Becker; Vera Kolatzki; Andreas Hochhaus; Martin Griesshammer; Kai Wille Journal: J Cancer Res Clin Oncol Date: 2020-11-02 Impact factor: 4.553
Authors: Mohammad Abu-Tineh; Nancy Kassem; Mohammad Abdul-Jaber Abdulla; Omar Mohammad Ismail; Rola Ghasoub; Mahmood B Aldapt; Mohamed A Yassin Journal: Case Rep Oncol Date: 2020-03-26
Authors: Chul Won Choi; Soo-Mee Bang; Seongsoo Jang; Chul Won Jung; Hee-Jin Kim; Ho Young Kim; Soo-Jeong Kim; Yeo-Kyeoung Kim; Jinny Park; Jong-Ho Won Journal: Korean J Intern Med Date: 2015-10-30 Impact factor: 2.884