| Literature DB >> 15589166 |
Amy E Wandstrat1, Charles Nguyen, Nisha Limaye, Alice Y Chan, Srividya Subramanian, Xiang-Hong Tian, Young-Sun Yim, Alexander Pertsemlidis, Harold R Garner, Laurence Morel, Edward K Wakeland.
Abstract
Susceptibility to autoimmunity in B6.Sle1b mice is associated with extensive polymorphisms between two divergent haplotypes of the SLAM/CD2 family of genes. The B6.Sle1b-derived SLAM/CD2 family haplotype is found in many other laboratory mouse strains but only causes autoimmunity in the context of the C57Bl/6 (B6) genome. Phenotypic analyses have revealed variations in the structure and expression of several members of the SLAM/CD2 family in T and B lymphocytes from B6.Sle1b mice. T lymphocytes from B6.Sle1b mice have modified signaling responses to stimulation at 4-6 weeks of age. While autoimmunity may be mediated by a combination of genes in the SLAM/CD2 family cluster, the strongest candidate is Ly108, a specific isoform of which is constitutively upregulated in B6.Sle1b lymphocytes.Entities:
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Year: 2004 PMID： 15589166 DOI： 10.1016/j.immuni.2004.10.009
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745