Literature DB >> 15589136

Signaling pathways: the benefits of good communication.

Tracey L Fisher1, Morris F White.   

Abstract

Recent studies show that hyperactivated mTOR, the 'target of rapamycin' that senses nutrient availability in eukaryotic cells, inhibits signaling by insulin receptor substrates. This crosstalk reveals how hyperactivated mTOR may suppress metastasis locally, while causing systemic insulin resistance that can progress to diabetes.

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Year:  2004        PMID： 15589136     DOI： 10.1016/j.cub.2004.11.024

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  20 in total

1.  Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.

Authors:  Martha L Slattery; Jennifer S Herrick; Abbie Lundgreen; Francis A Fitzpatrick; Karen Curtin; Roger K Wolff
Journal:  Carcinogenesis       Date:  2010-07-09       Impact factor: 4.944

2.  An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.

Authors:  Theresa R Bomfim; Leticia Forny-Germano; Luciana B Sathler; Jordano Brito-Moreira; Jean-Christophe Houzel; Helena Decker; Michael A Silverman; Hala Kazi; Helen M Melo; Paula L McClean; Christian Holscher; Steven E Arnold; Konrad Talbot; William L Klein; Douglas P Munoz; Sergio T Ferreira; Fernanda G De Felice
Journal:  J Clin Invest       Date:  2012-04       Impact factor: 14.808

3.  Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis.

Authors:  O Jameel Shah; Tony Hunter
Journal:  Mol Cell Biol       Date:  2006-09       Impact factor: 4.272

Review 4.  Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.

Authors:  Ramesh Kandimalla; Vani Thirumala; P Hemachandra Reddy
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2016-08-25       Impact factor: 5.187

5.  Metallothionein alleviates cardiac contractile dysfunction induced by insulin resistance: role of Akt phosphorylation, PTB1B, PPARgamma and c-Jun.

Authors:  C X Fang; F Dong; B H Ren; P N Epstein; J Ren
Journal:  Diabetologia       Date:  2005-09-20       Impact factor: 10.122

6.  Cardiac overexpression of catalase rescues cardiac contractile dysfunction induced by insulin resistance: Role of oxidative stress, protein carbonyl formation and insulin sensitivity.

Authors:  F Dong; C X Fang; X Yang; X Zhang; F L Lopez; J Ren
Journal:  Diabetologia       Date:  2006-04-04       Impact factor: 10.122

Review 7.  Deregulation of brain insulin signaling in Alzheimer's disease.

Authors:  Yanxing Chen; Yanqiu Deng; Baorong Zhang; Cheng-Xin Gong
Journal:  Neurosci Bull       Date:  2014-03-20       Impact factor: 5.203

8.  Insulin receptor substrate-2 in the ventral tegmental area regulates behavioral responses to cocaine.

Authors:  Sergio D Iñiguez; Brandon L Warren; Rachael L Neve; Eric J Nestler; Scott J Russo; Carlos A Bolaños-Guzmán
Journal:  Behav Neurosci       Date:  2008-10       Impact factor: 1.912

9.  Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice.

Authors:  Seongah Han; Chien-Ping Liang; Marit Westerterp; Takafumi Senokuchi; Carrie L Welch; Qizhi Wang; Michihiro Matsumoto; Domenico Accili; Alan R Tall
Journal:  J Clin Invest       Date:  2009-03-09       Impact factor: 14.808

10.  Identification of the degradation determinants of insulin receptor substrate 1 for signaling cullin-RING E3 ubiquitin ligase 7-mediated ubiquitination.

Authors:  Xinsong Xu; Malik Keshwani; Kathleen Meyer; Antonio Sarikas; Susan Taylor; Zhen-Qiang Pan
Journal:  J Biol Chem       Date:  2012-10-08       Impact factor: 5.157
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