Literature DB >> 15588127

LVV-hemorphin-7 lowers blood pressure in spontaneously hypertensive rats: radiotelemetry study.

J Cejka1, B Zelezná, J Velek, J Zicha, J Kunes.   

Abstract

Cardiovascular effects of LVV-hemorphin-7, a member of the family of fragments from beta-chain of human or bovine hemoglobin, were studied in conscious spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats by radiotelemetry. Intraperitoneal injection of hemorphin in a dose of 100 microg/kg significantly decreased blood pressure in SHR, whereas negligible effect was seen in normotensive WKY rats. Blood pressure changes were accompanied by reduction of heart rate. In conclusion, a direct effect of LVV-hemorphin-7 on blood pressure was demonstrated in SHR. These biologically active peptides could be involved in blood pressure regulation especially in hypertensive rats, but the precise mechanism should be elucidated.

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Year:  2004        PMID： 15588127

Source DB:  PubMed          Journal:  Physiol Res        ISSN： 0862-8408            Impact factor:   1.881


  8 in total

Review 1.  Hemoglobin-derived peptides as novel type of bioactive signaling molecules.

Authors:  Ivone Gomes; Camila S Dale; Kimbie Casten; Miriam A Geigner; Fabio C Gozzo; Emer S Ferro; Andrea S Heimann; Lakshmi A Devi
Journal:  AAPS J       Date:  2010-09-02       Impact factor: 4.009

2.  Molecular insights into the interaction of hemorphin and its targets.

Authors:  Amanat Ali; Bincy Baby; Soja Saghar Soman; Ranjit Vijayan
Journal:  Sci Rep       Date:  2019-10-14       Impact factor: 4.379

3.  Positive Modulation of Angiotensin II Type 1 Receptor-Mediated Signaling by LVV-Hemorphin-7.

Authors:  Amanat Ali; Abdulrasheed Palakkott; Arshida Ashraf; Isra Al Zamel; Bincy Baby; Ranjit Vijayan; Mohammed Akli Ayoub
Journal:  Front Pharmacol       Date:  2019-10-25       Impact factor: 5.810

Review 4.  Hemorphins Targeting G Protein-Coupled Receptors.

Authors:  Mohammed Akli Ayoub; Ranjit Vijayan
Journal:  Pharmaceuticals (Basel)       Date:  2021-03-07

Review 5.  Dysregulation in erythrocyte dynamics caused by SARS-CoV-2 infection: possible role in shuffling the homeostatic puzzle during COVID-19.

Authors:  Michelle Mendanha Mendonça; Kellen Rosa da Cruz; Denise da Silva Pinheiro; Gean Carlos Alves Moraes; Patricia Maria Ferreira; Marcos Luiz Ferreira-Neto; Eduardo Sérgio da Silva; Reggiani Vilela Gonçalves; Gustavo Rodrigues Pedrino; James O Fajemiroye; Carlos Henrique Xavier
Journal:  Hematol Transfus Cell Ther       Date:  2022-01-25

6.  Food-Derived Hemorphins Cross Intestinal and Blood-Brain Barriers In Vitro.

Authors:  Dorothée Domenger; Benoit Cudennec; Mostafa Kouach; Véronique Touche; Christophe Landry; Jean Lesage; Fabien Gosselet; Sophie Lestavel; Jean-François Goossens; Pascal Dhulster; Rozenn Ravallec
Journal:  Front Endocrinol (Lausanne)       Date:  2018-04-10       Impact factor: 5.555

7.  Camel Hemorphins Exhibit a More Potent Angiotensin-I Converting Enzyme Inhibitory Activity than Other Mammalian Hemorphins: An In Silico and In Vitro Study.

Authors:  Amanat Ali; Seham Abdullah Rashed Alzeyoudi; Shamma Abdulla Almutawa; Alya Nasir Alnajjar; Yusra Al Dhaheri; Ranjit Vijayan
Journal:  Biomolecules       Date:  2020-03-23

Review 8.  Allosteric Modulator Leads Hiding in Plain Site: Developing Peptide and Peptidomimetics as GPCR Allosteric Modulators.

Authors:  Keith M Olson; John R Traynor; Andrew Alt
Journal:  Front Chem       Date:  2021-10-07       Impact factor: 5.221
  8 in total

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